CDE Detailed Report

Disease: content
Sub-Domain: Classification
CRF: welcome

Displaying 1 - 25 of 25
CDE ID CDE Name Variable Name Definition Short Description Additional Notes (Question Text) Permissible Values Description Data Type Disease Specific Instructions Disease Specific Reference Population Classification (e.g., Core) Version Number Version Date CRF Name (CRF Module / Guideline) Sub Domain Name Domain Name Size Input Restrictions Min Value Max Value Measurement Type External Id Loinc External Id Snomed External Id caDSR External Id CDISC
C58590 Seizure focal impaired awareness non-motor present status SeizFocImpAwareNonMtrPresStat The status indicating the degree to which a non-motor focal impaired awareness seizure is present The status indicating the degree to which a non-motor focal impaired awareness seizure is present Focal Impaired Awareness-non-motor No;Possible;Definite;Unknown;N/A;Probably No;Possible;Definite;Unknown;N/A;Probably Alphanumeric

Without observable motor or autonomic components
Focal Impaired Awareness: This categorization should be used if a subject has focal seizure and they have confusion or difficulty understanding their environment or difficulty remembering what has occurred even in the absence of an altered level of consciousness.
No = Not present
Possible = The summary of evidence suggests less than 50% confidence level
Probable = The summary of evidence suggests greater than 50% confidence level
Definite = The summary of evidence suggests 100% confidence level
Unknown = The summary of evidence is not sufficient to support a finding
N/A = Not Applicable; to be used at the discretion of the Principal Investigator based on study design

Fisher RS, Cross JH, French JA, Higurashi N, Hirsch E, Jansen FE, Lagae L, Mosh&Eacute; SL, Peltola J, Roulet Perez E, Scheffer IE, Zuberi SM. Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology. Epilepsia 2017;58(4):522&#8211;530. <br />Fisher RS, Cross JH, D'Souza C, French JA, Haut SR, Higurashi N, Hirsch E, Jansen FE, Lagae L, Mosh&Eacute; SL, Peltola J, Roulet Perez E, Scheffer IE, Schulze-Bonhage A, Somerville E, Sperling M, Yacubian EM, Zuberi SM. Instruction manual for the ILAE 2017 operational classification of seizure types. Epilepsia 2017;58(4):531&#8211;542. Adult;Pediatric Supplemental 3.00 2013-07-30 14:29:49.047 Classification of Seizures Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58601 Seizure epilepsy generalized non-motor subtype type SeizEpilepsyGenNonMtrSubtypTyp The element related to type of non-motor generalized seizures the participant/subject is experiencing The element related to type of non-motor generalized seizures the participant/subject is experiencing Non-motor Absence NOS;Typical absence;Atypical absence;Myoclonic absence;Absence with eyelid myoclonia Absence NOS (Not otherwise specified);Typical absence;Atypical absence;Myoclonic absence;Absence with eyelid myoclonia Alphanumeric

(Absence)
Specify type

https://www.ilae.org/<br />Fisher RS, Cross JH, French JA, Higurashi N, Hirsch E, Jansen FE, Lagae L, Mosh&Eacute; SL, Peltola J, Roulet Perez E, Scheffer IE, Zuberi SM. Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology. Epilepsia 2017;58(4):522&#8211;530. <br />Fisher RS, Cross JH, D'Souza C, French JA, Haut SR, Higurashi N, Hirsch E, Jansen FE, Lagae L, Mosh&Eacute; SL, Peltola J, Roulet Perez E, Scheffer IE, Schulze-Bonhage A, Somerville E, Sperling M, Yacubian EM, Zuberi SM. Instruction manual for the ILAE 2017 operational classification of seizure types. Epilepsia 2017;58(4):531&#8211;542. Adult;Pediatric Supplemental 3.00 2013-08-28 16:08:00.453 Classification of Seizures Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58591 Seizure focal bilateral tonic clonic present status SeizFocBilatTonClonPresStat The status indicating the degree to which a focal to bilateral, tonic clonic seizure is present The status indicating the degree to which a focal to bilateral, tonic clonic seizure is present Focal to bilateral, tonic clonic seizure No;Possible;Definite;Unknown;N/A;Probably No;Possible;Definite;Unknown;N/A;Probably Alphanumeric

Involving tonic, followed by clonic movements, replaces the term "secondarily generalized seizure"
No = Not present
Possible = The summary of evidence suggests less than 50% confidence level
Probable = The summary of evidence suggests greater than 50% confidence level
Definite = The summary of evidence suggests 100% confidence level
Unknown = The summary of evidence is not sufficient to support a finding
N/A = Not Applicable; to be used at the discretion of the Principal Investigator based on study design

Fisher RS, Cross JH, French JA, Higurashi N, Hirsch E, Jansen FE, Lagae L, Mosh&Eacute; SL, Peltola J, Roulet Perez E, Scheffer IE, Zuberi SM. Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology. Epilepsia 2017;58(4):522&#8211;530. <br />Fisher RS, Cross JH, D'Souza C, French JA, Haut SR, Higurashi N, Hirsch E, Jansen FE, Lagae L, Mosh&Eacute; SL, Peltola J, Roulet Perez E, Scheffer IE, Schulze-Bonhage A, Somerville E, Sperling M, Yacubian EM, Zuberi SM. Instruction manual for the ILAE 2017 operational classification of seizure types. Epilepsia 2017;58(4):531&#8211;542. Adult;Pediatric Supplemental 3.00 2013-07-30 14:29:49.047 Classification of Seizures Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58602 Seizure epilepsy unknown onset subtype status SeizEpilUnknOnsetSubtypStat The element related to the degree to which a seizure of unknown onset is present The element related to the degree to which a seizure of unknown onset is present Seizure subtypes of Unknown onset No;Possible;Definite;Unknown;N/A;Probably No;Possible;Definite;Unknown;N/A;Probably Alphanumeric

Unknown if focal or generalized

https://www.ilae.org/<br />Fisher RS, Cross JH, French JA, Higurashi N, Hirsch E, Jansen FE, Lagae L, Mosh&Eacute; SL, Peltola J, Roulet Perez E, Scheffer IE, Zuberi SM. Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology. Epilepsia 2017;58(4):522&#8211;530. <br />Fisher RS, Cross JH, D'Souza C, French JA, Haut SR, Higurashi N, Hirsch E, Jansen FE, Lagae L, Mosh&Eacute; SL, Peltola J, Roulet Perez E, Scheffer IE, Schulze-Bonhage A, Somerville E, Sperling M, Yacubian EM, Zuberi SM. Instruction manual for the ILAE 2017 operational classification of seizure types. Epilepsia 2017;58(4):531&#8211;542. Adult;Pediatric Supplemental 3.00 2013-08-28 16:08:00.453 Classification of Seizures Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C06005 Data collected date and time DataCollDateTime Date (and time, if applicable and known) the data were collected. This may be the date/time a particular examination or procedure was performed. Date (and time, if applicable and known) the data were collected. This may be the date/time a particular examination or procedure was performed. Date form completed Date or Date & Time

Record the date/time according to the ISO 8601, the International Standard for the representation of dates and times (http://www.iso.org/iso/home.html). The date/time should be recorded to the level of granularity known (e.g., year, year and month, complete date plus hours and minutes, etc.).

https://www.ilae.org/<br />Fisher RS, Cross JH, French JA, Higurashi N, Hirsch E, Jansen FE, Lagae L, Mosh&Eacute; SL, Peltola J, Roulet Perez E, Scheffer IE, Zuberi SM. Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology. Epilepsia 2017;58(4):522-530. <br />Fisher RS, Cross JH, D'Souza C, French JA, Haut SR, Higurashi N, Hirsch E, Jansen FE, Lagae L, Mosh&Eacute; SL, Peltola J, Roulet Perez E, Scheffer IE, Schulze-Bonhage A, Somerville E, Sperling M, Yacubian EM, Zuberi SM. Instruction manual for the ILAE 2017 operational classification of seizure types. Epilepsia 2017;58(4):531-542. Adult;Pediatric Supplemental-Highly Recommended 3.00 2013-07-24 21:00:23.88 Classification of Seizures Classification Disease/Injury Related Events

Free-Form Entry

C58592 Seizure focal unknown aware present status SeizFocUnknwnAwarePresStat The status indicating the degree to which a focal, unknown awareness seizure is present The status indicating the degree to which a focal, unknown awareness seizure is present Focal, unknown awareness No;Possible;Definite;Unknown;N/A;Probably No;Possible;Definite;Unknown;N/A;Probably Alphanumeric

If a seizure is definitely focal, but awareness is unknown, please use the Focal Unknown Awareness categorization
No = Not present
Possible = The summary of evidence suggests less than 50% confidence level
Probable = The summary of evidence suggests greater than 50% confidence level
Definite = The summary of evidence suggests 100% confidence level
Unknown = The summary of evidence is not sufficient to support a finding
N/A = Not Applicable; to be used at the discretion of the Principal Investigator based on study design

Fisher RS, Cross JH, French JA, Higurashi N, Hirsch E, Jansen FE, Lagae L, Mosh&Eacute; SL, Peltola J, Roulet Perez E, Scheffer IE, Zuberi SM. Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology. Epilepsia 2017;58(4):522&#8211;530. <br />Fisher RS, Cross JH, D'Souza C, French JA, Haut SR, Higurashi N, Hirsch E, Jansen FE, Lagae L, Mosh&Eacute; SL, Peltola J, Roulet Perez E, Scheffer IE, Schulze-Bonhage A, Somerville E, Sperling M, Yacubian EM, Zuberi SM. Instruction manual for the ILAE 2017 operational classification of seizure types. Epilepsia 2017;58(4):531&#8211;542. Adult;Pediatric Supplemental 3.00 2013-07-30 14:29:49.047 Classification of Seizures Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58603 Seizure epilepsy unknown onset subtype type SeizEpilepsyUnknOnsSubtypTyp The element related to type of unknown onset seizures the participant/subject is experiencing The element related to type of unknown onset seizures the participant/subject is experiencing Seizure subtypes of Unknown onset Generalized tonic-clonic;Motor NOS;Clonic;Tonic;Myoclonic;Atonic;Epileptic spasms;Non-motor NOS Generalized tonic-clonic;Motor NOS (not otherwise specified);Clonic;Tonic;Myoclonic;Atonic;Epileptic spasms;Non-motor NOS (not otherwise specified) Alphanumeric

Unknown if focal or generalized
Tonic, clonic, atonic and epileptic spasm: When these seizure types occur in patients with combined focal and generalized epilepsy, it is often difficult to determine whether their onset is focal or generalized. Please use the Unknown Onset box in these cases. (e.g., Lennox Gastaut Syndrome).

https://www.ilae.org/<br />Fisher RS, Cross JH, French JA, Higurashi N, Hirsch E, Jansen FE, Lagae L, Mosh&Eacute; SL, Peltola J, Roulet Perez E, Scheffer IE, Zuberi SM. Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology. Epilepsia 2017;58(4):522&#8211;530. <br />Fisher RS, Cross JH, D'Souza C, French JA, Haut SR, Higurashi N, Hirsch E, Jansen FE, Lagae L, Mosh&Eacute; SL, Peltola J, Roulet Perez E, Scheffer IE, Schulze-Bonhage A, Somerville E, Sperling M, Yacubian EM, Zuberi SM. Instruction manual for the ILAE 2017 operational classification of seizure types. Epilepsia 2017;58(4):531&#8211;542. Adult;Pediatric Supplemental 3.00 2013-08-28 16:08:00.453 Classification of Seizures Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C14134 Data valid through date and time DataValidThroughDateTime Date (and time, if applicable and known) the data collected are valid through Date the data collected are valid through Information complete up to Date or Date & Time

Record the date/time according to the ISO 8601, the International Standard for the representation of dates and times (http://www.iso.org/iso/home.html). The date/time should be recorded to the level of granularity known (e.g., year, year and month, complete date plus hours and minutes, etc.).

Adult;Pediatric Supplemental-Highly Recommended 3.00 2013-08-28 16:08:00.453 Classification of Seizures Classification Disease/Injury Related Events

Free-Form Entry

C58593 Seizure focal unknown awareness observable motor present status SeizFocUnkAwarObsvMtrPresStat The status indicating the degree to which a focal, unknown awareness seizure with observable motor is present The status indicating the degree to which a focal, unknown awareness seizure with observable motor is present With observable motor No;Possible;Definite;Unknown;N/A;Probably No;Possible;Definite;Unknown;N/A;Probably Alphanumeric

No = Not present
Possible = The summary of evidence suggests less than 50% confidence level
Probable = The summary of evidence suggests greater than 50% confidence level
Definite = The summary of evidence suggests 100% confidence level
Unknown = The summary of evidence is not sufficient to support a finding
N/A = Not Applicable; to be used at the discretion of the Principal Investigator based on study design

Fisher RS, Cross JH, French JA, Higurashi N, Hirsch E, Jansen FE, Lagae L, Mosh&Eacute; SL, Peltola J, Roulet Perez E, Scheffer IE, Zuberi SM. Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology. Epilepsia 2017;58(4):522&#8211;530. <br />Fisher RS, Cross JH, D'Souza C, French JA, Haut SR, Higurashi N, Hirsch E, Jansen FE, Lagae L, Mosh&Eacute; SL, Peltola J, Roulet Perez E, Scheffer IE, Schulze-Bonhage A, Somerville E, Sperling M, Yacubian EM, Zuberi SM. Instruction manual for the ILAE 2017 operational classification of seizure types. Epilepsia 2017;58(4):531&#8211;542. Adult;Pediatric Supplemental 3.00 2013-07-30 14:29:49.047 Classification of Seizures Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58604 Seizure unclassified classification status SeizUnclassClassStat The element related to the degree to which unclassified seizures are present The element related to the degree to which unclassified seizures are present Seizure type is unclassified: No;Possible;Definite;Unknown;N/A;Probably No;Possible;Definite;Unknown;N/A;Probably Alphanumeric

No = Not present
Possible = The summary of evidence suggests less than 50% confidence level
Probable = The summary of evidence suggests greater than 50% confidence level
Definite = The summary of evidence suggests 100% confidence level
Unknown = The summary of evidence is not sufficient to support a finding
N/A = Not Applicable; to be used at the discretion of the Principal Investigator based on study design

https://www.ilae.org/<br />Fisher RS, Cross JH, French JA, Higurashi N, Hirsch E, Jansen FE, Lagae L, Mosh&Eacute; SL, Peltola J, Roulet Perez E, Scheffer IE, Zuberi SM. Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology. Epilepsia 2017;58(4):522&#8211;530. <br />Fisher RS, Cross JH, D'Souza C, French JA, Haut SR, Higurashi N, Hirsch E, Jansen FE, Lagae L, Mosh&Eacute; SL, Peltola J, Roulet Perez E, Scheffer IE, Schulze-Bonhage A, Somerville E, Sperling M, Yacubian EM, Zuberi SM. Instruction manual for the ILAE 2017 operational classification of seizure types. Epilepsia 2017;58(4):531&#8211;542. Adult;Pediatric Supplemental-Highly Recommended 3.00 2013-08-28 16:08:00.453 Classification of Seizures Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58581 Seizure epilepsy classification type SeizEpilepsyClassTyp The type of epileptic seizure(s) the participant/subject experiences The type of epileptic seizure(s) the participant/subject experiences Classification of seizures Generalized;Focal;Unclassified;Unknown if generalized or focal Generalized;Focal;Unclassified seizures are considered unidentifiable due to lack of data and do not fit in to the aforementioned categories for Generalized and Focal Seizures;Unknown if generalized or focal Alphanumeric

Check all that apply.
It is possible for a participant/subject to have more than one seizure type.
Focal - complete questions for focal seizure subtypes
Generalized - complete questions for Generalized seizure subtypes
Unclassified - complete questions for Unclassified seizure subtype

https://www.ilae.org/<br />Fisher RS, Cross JH, French JA, Higurashi N, Hirsch E, Jansen FE, Lagae L, Mosh&Eacute; SL, Peltola J, Roulet Perez E, Scheffer IE, Zuberi SM. Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology. Epilepsia 2017;58(4):522&#8211;530. <br />Fisher RS, Cross JH, D'Souza C, French JA, Haut SR, Higurashi N, Hirsch E, Jansen FE, Lagae L, Mosh&Eacute; SL, Peltola J, Roulet Perez E, Scheffer IE, Schulze-Bonhage A, Somerville E, Sperling M, Yacubian EM, Zuberi SM. Instruction manual for the ILAE 2017 operational classification of seizure types. Epilepsia 2017;58(4):531&#8211;542. Adult;Pediatric Core 3.00 2013-08-28 16:08:00.453 Classification of Seizures Classification Disease/Injury Related Events

Multiple Pre-Defined Values Selected

C58594 Seizure focal unknown awareness no observable motor present status SeizFocUnkAwarNoObsvMtrPrsStat The status indicating the degree to which a focal, unknown awareness seizure without observable motor is present The status indicating the degree to which a focal, unknown awareness seizure without observable motor is present Without observable motor No;Possible;Definite;Unknown;N/A;Probably No;Possible;Definite;Unknown;N/A;Probably Alphanumeric

No = Not present
Possible = The summary of evidence suggests less than 50% confidence level
Probable = The summary of evidence suggests greater than 50% confidence level
Definite = The summary of evidence suggests 100% confidence level
Unknown = The summary of evidence is not sufficient to support a finding
N/A = Not Applicable; to be used at the discretion of the Principal Investigator based on study design

Fisher RS, Cross JH, French JA, Higurashi N, Hirsch E, Jansen FE, Lagae L, Mosh&Eacute; SL, Peltola J, Roulet Perez E, Scheffer IE, Zuberi SM. Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology. Epilepsia 2017;58(4):522&#8211;530. <br />Fisher RS, Cross JH, D'Souza C, French JA, Haut SR, Higurashi N, Hirsch E, Jansen FE, Lagae L, Mosh&Eacute; SL, Peltola J, Roulet Perez E, Scheffer IE, Schulze-Bonhage A, Somerville E, Sperling M, Yacubian EM, Zuberi SM. Instruction manual for the ILAE 2017 operational classification of seizure types. Epilepsia 2017;58(4):531&#8211;542. Adult;Pediatric Supplemental 3.00 2013-07-30 14:29:49.047 Classification of Seizures Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58607 Seizure epilepsy generalized subtype status SeizEpilGenSubtypStat The element related to the degree to which a generalized seizure is present The element related to the degree to which a generalized seizure is present Generalized Seizure Subtypes No;Possible;Definite;Unknown;N/A;Probably No;Possible;Definite;Unknown;N/A;Probably Alphanumeric

No = Not present
Possible = The summary of evidence suggests less than 50% confidence level
Probable = The summary of evidence suggests greater than 50% confidence level
Definite = The summary of evidence suggests 100% confidence level
Unknown = The summary of evidence is not sufficient to support a finding
N/A = Not Applicable; to be used at the discretion of the Principal Investigator based on study design

Fisher RS, Cross JH, French JA, Higurashi N, Hirsch E, Jansen FE, Lagae L, Mosh&Eacute; SL, Peltola J, Roulet Perez E, Scheffer IE, Zuberi SM. Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology. Epilepsia 2017;58(4):522&#8211;530. <br />Fisher RS, Cross JH, D'Souza C, French JA, Haut SR, Higurashi N, Hirsch E, Jansen FE, Lagae L, Mosh&Eacute; SL, Peltola J, Roulet Perez E, Scheffer IE, Schulze-Bonhage A, Somerville E, Sperling M, Yacubian EM, Zuberi SM. Instruction manual for the ILAE 2017 operational classification of seizure types. Epilepsia 2017;58(4):531&#8211;542. Adult;Pediatric Supplemental 3.00 2013-07-30 14:29:49.047 Classification of Seizures Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58583 Seizure epilepsy focal classification type SeizEpilepsyFocClassTyp The type of focal epileptic seizures, considered to originate within networks limited to one hemisphere, which may be discretely localized or more widely distributed, and may originate in subcortical structures, experience by the participant/subject. The type of focal epileptic seizures, considered to originate within networks limited to one hemisphere, which may be discretely localized or more widely distributed, and may originate in subcortical structures, experience by the participant/subject. Focal Seizure Subtypes Focal aware;Focal Impaired Awareness;Focal to bilateral, tonic clonic seizure;Focal, unknown awareness;Focal onset Clonic;Focal onset Tonic;Focal onset Atonic;Focal onset Epileptic spasm Focal aware (without impairment of awareness);Focal Impaired Awareness (with impairment of awareness (roughly corresponds to the the concept of ''complex partial seizure''));Focal to bilateral, tonic clonic seizure (involving tonic, folowed by clonic movements, replaces the term ''secondarily generalized seizure'');Focal, unknown awareness;Focal onset Clonic;Focal onset Tonic;Focal onset Atonic;Focal onset Epileptic spasm Alphanumeric

Per degree of impairment
Tonic, clonic, atonic and epileptic spasm: When these seizure types occur in patients with combined focal and generalized epilepsy, it is often difficult to determine whether their onset is focal or generalized. Please use the Unknown Onset box in these cases. (e.g., Lennox Gastaut Syndrome).
It is possible for a participant/subject to have more than one seizure type. For each seizure type, ictal onset is consistent from one seizure to another with preferential propagation patterns, which can involve the contralateral hemisphere. In some cases, however, there is more than one epileptogenic network, and more than one seizure type, but each individual seizure type has a consistent site of onset. Focal seizures do not fall into any recognized set of natural classes based on any current understanding of the mechanisms involved.

https://www.ilae.org/<br />Fisher RS, Cross JH, French JA, Higurashi N, Hirsch E, Jansen FE, Lagae L, Mosh&Eacute; SL, Peltola J, Roulet Perez E, Scheffer IE, Zuberi SM. Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology. Epilepsia 2017;58(4):522&#8211;530. <br />Fisher RS, Cross JH, D'Souza C, French JA, Haut SR, Higurashi N, Hirsch E, Jansen FE, Lagae L, Mosh&Eacute; SL, Peltola J, Roulet Perez E, Scheffer IE, Schulze-Bonhage A, Somerville E, Sperling M, Yacubian EM, Zuberi SM. Instruction manual for the ILAE 2017 operational classification of seizure types. Epilepsia 2017;58(4):531&#8211;542. Adult;Pediatric Supplemental-Highly Recommended 3.00 2013-08-28 16:08:00.453 Classification of Seizures Classification Disease/Injury Related Events

Multiple Pre-Defined Values Selected

C58595 Seizure focal onset clonic present status SeizFocOnsetClonicPresStat The status indicating the degree to which a focal onset clonic seizure is present The status indicating the degree to which a focal onset clonic seizure is present Focal onset Clonic No;Possible;Definite;Unknown;N/A;Probably No;Possible;Definite;Unknown;N/A;Probably Alphanumeric

No = Not present
Possible = The summary of evidence suggests less than 50% confidence level
Probable = The summary of evidence suggests greater than 50% confidence level
Definite = The summary of evidence suggests 100% confidence level
Unknown = The summary of evidence is not sufficient to support a finding
N/A = Not Applicable; to be used at the discretion of the Principal Investigator based on study design

Fisher RS, Cross JH, French JA, Higurashi N, Hirsch E, Jansen FE, Lagae L, Mosh&Eacute; SL, Peltola J, Roulet Perez E, Scheffer IE, Zuberi SM. Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology. Epilepsia 2017;58(4):522&#8211;530. <br />Fisher RS, Cross JH, D'Souza C, French JA, Haut SR, Higurashi N, Hirsch E, Jansen FE, Lagae L, Mosh&Eacute; SL, Peltola J, Roulet Perez E, Scheffer IE, Schulze-Bonhage A, Somerville E, Sperling M, Yacubian EM, Zuberi SM. Instruction manual for the ILAE 2017 operational classification of seizure types. Epilepsia 2017;58(4):531&#8211;542. Adult;Pediatric Supplemental 3.00 2013-07-30 14:29:49.047 Classification of Seizures Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58584 Seizure focal aware present status SeizFocAwarePresentStat The status indicating the degree to which a focal aware seizure is present The status indicating the degree to which a focal aware seizure is present Focal aware No;Possible;Definite;Unknown;N/A;Probably No;Possible;Definite;Unknown;N/A;Probably Alphanumeric

Without impairment of awareness
No = Not present
Possible = The summary of evidence suggests less than 50% confidence level
Probable = The summary of evidence suggests greater than 50% confidence level
Definite = The summary of evidence suggests 100% confidence level
Unknown = The summary of evidence is not sufficient to support a finding
N/A = Not Applicable; to be used at the discretion of the Principal Investigator based on study design

https://www.ilae.org/<br />Fisher RS, Cross JH, French JA, Higurashi N, Hirsch E, Jansen FE, Lagae L, Mosh&Eacute; SL, Peltola J, Roulet Perez E, Scheffer IE, Zuberi SM. Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology. Epilepsia 2017;58(4):522&#8211;530. <br />Fisher RS, Cross JH, D'Souza C, French JA, Haut SR, Higurashi N, Hirsch E, Jansen FE, Lagae L, Mosh&Eacute; SL, Peltola J, Roulet Perez E, Scheffer IE, Schulze-Bonhage A, Somerville E, Sperling M, Yacubian EM, Zuberi SM. Instruction manual for the ILAE 2017 operational classification of seizure types. Epilepsia 2017;58(4):531&#8211;542. Adult;Pediatric Supplemental 3.00 2013-07-30 14:29:49.047 Classification of Seizures Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58596 Seizure focal onset tonic present status SeizFocOnsetTonicPresStat The status indicating the degree to which a focal onset tonic seizure is present The status indicating the degree to which a focal onset tonic seizure is present Focal onset Tonic No;Possible;Definite;Unknown;N/A;Probably No;Possible;Definite;Unknown;N/A;Probably Alphanumeric

No = Not present
Possible = The summary of evidence suggests less than 50% confidence level
Probable = The summary of evidence suggests greater than 50% confidence level
Definite = The summary of evidence suggests 100% confidence level
Unknown = The summary of evidence is not sufficient to support a finding
N/A = Not Applicable; to be used at the discretion of the Principal Investigator based on study design

Fisher RS, Cross JH, French JA, Higurashi N, Hirsch E, Jansen FE, Lagae L, Mosh&Eacute; SL, Peltola J, Roulet Perez E, Scheffer IE, Zuberi SM. Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology. Epilepsia 2017;58(4):522&#8211;530. <br />Fisher RS, Cross JH, D'Souza C, French JA, Haut SR, Higurashi N, Hirsch E, Jansen FE, Lagae L, Mosh&Eacute; SL, Peltola J, Roulet Perez E, Scheffer IE, Schulze-Bonhage A, Somerville E, Sperling M, Yacubian EM, Zuberi SM. Instruction manual for the ILAE 2017 operational classification of seizure types. Epilepsia 2017;58(4):531&#8211;542. Adult;Pediatric Supplemental 3.00 2013-07-30 14:29:49.047 Classification of Seizures Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58585 Seizure focal aware motor present status SeizFocAwareMotorPresentStat The status indicating the degree to which a motor/observable focal aware seizure is present The status indicating the degree to which a motor/observable focal aware seizure is present Focal aware-motor/observable No;Possible;Definite;Unknown;N/A;Probably No;Possible;Definite;Unknown;N/A;Probably Alphanumeric

With observable motor or autonomic components
No = Not present
Possible = The summary of evidence suggests less than 50% confidence level
Probable = The summary of evidence suggests greater than 50% confidence level
Definite = The summary of evidence suggests 100% confidence level
Unknown = The summary of evidence is not sufficient to support a finding
N/A = Not Applicable; to be used at the discretion of the Principal Investigator based on study design
With observable motor or autonomic components

Fisher RS, Cross JH, French JA, Higurashi N, Hirsch E, Jansen FE, Lagae L, Mosh&Eacute; SL, Peltola J, Roulet Perez E, Scheffer IE, Zuberi SM. Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology. Epilepsia 2017;58(4):522&#8211;530. <br />Fisher RS, Cross JH, D'Souza C, French JA, Haut SR, Higurashi N, Hirsch E, Jansen FE, Lagae L, Mosh&Eacute; SL, Peltola J, Roulet Perez E, Scheffer IE, Schulze-Bonhage A, Somerville E, Sperling M, Yacubian EM, Zuberi SM. Instruction manual for the ILAE 2017 operational classification of seizure types. Epilepsia 2017;58(4):531&#8211;542. Adult;Pediatric Supplemental 3.00 2013-07-30 14:29:49.047 Classification of Seizures Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58597 Seizure focal onset atonic present status SeizFocOnsetAtonicPresStat The status indicating the degree to which a focal onset atonic seizure is present The status indicating the degree to which a focal onset atonic seizure is present Focal onset Atonic No;Possible;Definite;Unknown;N/A;Probably No;Possible;Definite;Unknown;N/A;Probably Alphanumeric

No = Not present
Possible = The summary of evidence suggests less than 50% confidence level
Probable = The summary of evidence suggests greater than 50% confidence level
Definite = The summary of evidence suggests 100% confidence level
Unknown = The summary of evidence is not sufficient to support a finding
N/A = Not Applicable; to be used at the discretion of the Principal Investigator based on study design

Fisher RS, Cross JH, French JA, Higurashi N, Hirsch E, Jansen FE, Lagae L, Mosh&Eacute; SL, Peltola J, Roulet Perez E, Scheffer IE, Zuberi SM. Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology. Epilepsia 2017;58(4):522&#8211;530. <br />Fisher RS, Cross JH, D'Souza C, French JA, Haut SR, Higurashi N, Hirsch E, Jansen FE, Lagae L, Mosh&Eacute; SL, Peltola J, Roulet Perez E, Scheffer IE, Schulze-Bonhage A, Somerville E, Sperling M, Yacubian EM, Zuberi SM. Instruction manual for the ILAE 2017 operational classification of seizure types. Epilepsia 2017;58(4):531&#8211;542. Adult;Pediatric Supplemental 3.00 2013-07-30 14:29:49.047 Classification of Seizures Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58586 Seizure focal aware non-motor present status SeizFocAwareNonMotorPresStat The status indicating the degree to which a non-motor focal aware seizure is present The status indicating the degree to which a non-motor focal aware seizure is present Focal aware-non-motor No;Possible;Definite;Unknown;N/A;Probably No;Possible;Definite;Unknown;N/A;Probably Alphanumeric

Involving subjective sensory or psychic phenomena only
No = Not present
Possible = The summary of evidence suggests less than 50% confidence level
Probable = The summary of evidence suggests greater than 50% confidence level
Definite = The summary of evidence suggests 100% confidence level
Unknown = The summary of evidence is not sufficient to support a finding
N/A = Not Applicable; to be used at the discretion of the Principal Investigator based on study design

Fisher RS, Cross JH, French JA, Higurashi N, Hirsch E, Jansen FE, Lagae L, Mosh&Eacute; SL, Peltola J, Roulet Perez E, Scheffer IE, Zuberi SM. Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology. Epilepsia 2017;58(4):522&#8211;530. <br />Fisher RS, Cross JH, D'Souza C, French JA, Haut SR, Higurashi N, Hirsch E, Jansen FE, Lagae L, Mosh&Eacute; SL, Peltola J, Roulet Perez E, Scheffer IE, Schulze-Bonhage A, Somerville E, Sperling M, Yacubian EM, Zuberi SM. Instruction manual for the ILAE 2017 operational classification of seizure types. Epilepsia 2017;58(4):531&#8211;542. Adult;Pediatric Supplemental 3.00 2013-07-30 14:29:49.047 Classification of Seizures Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58598 Seizure focal onset epileptic spasm present status SeizFocOnsetEpilepSpasmPrsStat The status indicating the degree to which a focal onset epileptic spasm seizure is present The status indicating the degree to which a focal onset epileptic spasm seizure is present Focal onset Epileptic spasm No;Possible;Definite;Unknown;N/A;Probably No;Possible;Definite;Unknown;N/A;Probably Alphanumeric

No = Not present
Possible = The summary of evidence suggests less than 50% confidence level
Probable = The summary of evidence suggests greater than 50% confidence level
Definite = The summary of evidence suggests 100% confidence level
Unknown = The summary of evidence is not sufficient to support a finding
N/A = Not Applicable; to be used at the discretion of the Principal Investigator based on study design

Fisher RS, Cross JH, French JA, Higurashi N, Hirsch E, Jansen FE, Lagae L, Mosh&Eacute; SL, Peltola J, Roulet Perez E, Scheffer IE, Zuberi SM. Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology. Epilepsia 2017;58(4):522&#8211;530. <br />Fisher RS, Cross JH, D'Souza C, French JA, Haut SR, Higurashi N, Hirsch E, Jansen FE, Lagae L, Mosh&Eacute; SL, Peltola J, Roulet Perez E, Scheffer IE, Schulze-Bonhage A, Somerville E, Sperling M, Yacubian EM, Zuberi SM. Instruction manual for the ILAE 2017 operational classification of seizure types. Epilepsia 2017;58(4):531&#8211;542. Adult;Pediatric Supplemental 3.00 2013-07-30 14:29:49.047 Classification of Seizures Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58588 Seizure focal impaired awareness present status SeizFocImpairAwarePresentStat The status indicating the degree to which a focal impaired awareness seizure is present The status indicating the degree to which a focal impaired awareness seizure is present Focal Impaired Awareness No;Possible;Definite;Unknown;N/A;Probably No;Possible;Definite;Unknown;N/A;Probably Alphanumeric

With impairment of awareness (roughly corresponds to the concept of "complex partial seizure")
Focal Impaired Awareness: This categorization should be used if a subject has focal seizure and they have confusion or difficulty understanding their environment or difficulty remembering what has occurred even in the absence of an altered level of consciousness.
No = Not present
Possible = The summary of evidence suggests less than 50% confidence level
Probable = The summary of evidence suggests greater than 50% confidence level
Definite = The summary of evidence suggests 100% confidence level
Unknown = The summary of evidence is not sufficient to support a finding
N/A = Not Applicable; to be used at the discretion of the Principal Investigator based on study design

Fisher RS, Cross JH, French JA, Higurashi N, Hirsch E, Jansen FE, Lagae L, Mosh&Eacute; SL, Peltola J, Roulet Perez E, Scheffer IE, Zuberi SM. Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology. Epilepsia 2017;58(4):522&#8211;530. <br />Fisher RS, Cross JH, D'Souza C, French JA, Haut SR, Higurashi N, Hirsch E, Jansen FE, Lagae L, Mosh&Eacute; SL, Peltola J, Roulet Perez E, Scheffer IE, Schulze-Bonhage A, Somerville E, Sperling M, Yacubian EM, Zuberi SM. Instruction manual for the ILAE 2017 operational classification of seizure types. Epilepsia 2017;58(4):531&#8211;542. Adult;Pediatric Supplemental 3.00 2013-07-30 14:29:49.047 Classification of Seizures Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58599 Seizure epilepsy generalized classification type SeizEpilepsyGenClassTyp The type of generalized epileptic seizures, considered to originate at some point within, and rapidly engage, bilaterally distributed networks and may include such bilateral networks as cortical and subcortical structures, but do not necessarily include the entire cortex, experienced by the participant/subject. The type of generalized epileptic seizures, considered to originate at some point within, and rapidly engage, bilaterally distributed networks and may include such bilateral networks Generalized Seizure Subtypes Motor;Non-motor Motor;Non-motor (absence) Alphanumeric

Answer all. If a seizure cannot be adequately classified, it should not be fit into a category to which it does not belong.
Specify type below
It is possible for a participant/subject to have more than one seizure type. Although individual seizure onsets can appear localized, the location and lateralization are not consistent from one seizure to another. Generalized seizures can be asymmetric.

Fisher RS, Cross JH, French JA, Higurashi N, Hirsch E, Jansen FE, Lagae L, Mosh&Eacute; SL, Peltola J, Roulet Perez E, Scheffer IE, Zuberi SM. Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology. Epilepsia 2017;58(4):522&#8211;530. <br />Fisher RS, Cross JH, D'Souza C, French JA, Haut SR, Higurashi N, Hirsch E, Jansen FE, Lagae L, Mosh&Eacute; SL, Peltola J, Roulet Perez E, Scheffer IE, Schulze-Bonhage A, Somerville E, Sperling M, Yacubian EM, Zuberi SM. Instruction manual for the ILAE 2017 operational classification of seizure types. Epilepsia 2017;58(4):531&#8211;542. Adult;Pediatric Supplemental-Highly Recommended 3.00 2013-08-28 16:08:00.453 Classification of Seizures Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58589 Seizure focal impaired awareness motor present status SeizFocImpairAwareMtrPresStat The status indicating the degree to which a motor/observable focal impaired awareness seizure is present The status indicating the degree to which a motor/observable focal impaired awareness seizure is present Focal impaired awareness-motor/observable No;Possible;Definite;Unknown;N/A;Probably No;Possible;Definite;Unknown;N/A;Probably Alphanumeric

With observable motor or autonomic components
Focal Impaired Awareness: This categorization should be used if a subject has focal seizure and they have confusion or difficulty understanding their environment or difficulty remembering what has occurred even in the absence of an altered level of consciousness.
No = Not present
Possible = The summary of evidence suggests less than 50% confidence level
Probable = The summary of evidence suggests greater than 50% confidence level
Definite = The summary of evidence suggests 100% confidence level
Unknown = The summary of evidence is not sufficient to support a finding
N/A = Not Applicable; to be used at the discretion of the Principal Investigator based on study design

Fisher RS, Cross JH, French JA, Higurashi N, Hirsch E, Jansen FE, Lagae L, Mosh&Eacute; SL, Peltola J, Roulet Perez E, Scheffer IE, Zuberi SM. Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology. Epilepsia 2017;58(4):522&#8211;530. <br />Fisher RS, Cross JH, D'Souza C, French JA, Haut SR, Higurashi N, Hirsch E, Jansen FE, Lagae L, Mosh&Eacute; SL, Peltola J, Roulet Perez E, Scheffer IE, Schulze-Bonhage A, Somerville E, Sperling M, Yacubian EM, Zuberi SM. Instruction manual for the ILAE 2017 operational classification of seizure types. Epilepsia 2017;58(4):531&#8211;542. Adult;Pediatric Supplemental 3.00 2013-07-30 14:29:49.047 Classification of Seizures Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58600 Seizure epilepsy generalized motor subtype type SeizEpilepsyGenMotorSubtypTyp The element related to type of motor generalized seizures the participant/subject is experiencing The element related to type of motor generalized seizures the participant/subject is experiencing Motor: Myoclonic-tonic-clonic;Clonic;Myoclonic;Tonic;Atonic;Generalized tonic-clonic;Epileptic spasms;Not otherwise specified Myoclonic-tonic-clonic;Clonic;Myoclonic (not otherwise specified);Tonic;Atonic;Generalized tonic-clonic;Epileptic spasms;Not otherwise specified Alphanumeric

Specify type.
Tonic, clonic, atonic and epileptic spasm: When these seizure types occur in patients with combined focal and generalized epilepsy, it is often difficult to determine whether their onset is focal or generalized. Please use the Unknown Onset box in these cases. (e.g., Lennox Gastaut Syndrome).

https://www.ilae.org/<br />Fisher RS, Cross JH, French JA, Higurashi N, Hirsch E, Jansen FE, Lagae L, Mosh&Eacute; SL, Peltola J, Roulet Perez E, Scheffer IE, Zuberi SM. Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology. Epilepsia 2017;58(4):522&#8211;530. <br />Fisher RS, Cross JH, D'Souza C, French JA, Haut SR, Higurashi N, Hirsch E, Jansen FE, Lagae L, Mosh&Eacute; SL, Peltola J, Roulet Perez E, Scheffer IE, Schulze-Bonhage A, Somerville E, Sperling M, Yacubian EM, Zuberi SM. Instruction manual for the ILAE 2017 operational classification of seizure types. Epilepsia 2017;58(4):531&#8211;542. Adult;Pediatric Supplemental 3.00 2013-08-28 16:08:00.453 Classification of Seizures Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

CSV