CDEs in Use

While the use of CDEs is not currently a requirement, researchers who receive funding from NINDS are asked to use the CDEs in their case report forms (CRFs) and data management systems whenever possible (PAR-11-173 and PAR-10-199). NINDS-funded studies currently using the CDEs are listed below.


  • Imaging the Effect of Centrotemporal Spikes and Seizures on Language in Children (FIRST) [ identifier: NCT01521130]
  • Childhood Absence Epilepsy Rx PK-PD-Pharmacogenetics Study [ identifier: NCT00088452]
  • Maternal and Neurodevelopmental Outcomes of in Utero Antiepileptic Drug (AED) Exposure (MONEAD) [ identifier: NCT01730170]
  • Established Status Epilepticus Treatment Trial (ESETT) [ identifier: NCT01960075]


  • Neurocysticercosis: Combined Treatment With Praziquantel (PZQ) and Albendazole (ABZ) [ identifier: NCT00441285]


  • The Childhood and Adolescent Migraine Prevention Study (CHAMP) [ identifier: NCT01581281]

Multiple Sclerosis

  • A Phase 2 Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety, Tolerability and Activity of Ibudilast (MN-166) in Subjects with Progressive Multiple Sclerosis [ identifier: NCT01982942] (from NeuroNEXT Network)
  • Safety, Tolerability and Activity Study of Ibudilast in Subjects With Progressive Multiple Sclerosis [ identifier: NCT01982942]

Myasthenia Gravis

  • Phase II Trial of Rituximab In Myasthenia Gravis [ identifier: NCT02110706] (from NeuroNEXT Network)

Parkinson's Disease

  • Endurance Exercise in Parkinson Disease (DOSE PD) [ identifier: NCT01506479]
  • Effects of Non-invasive Neurostimulation Methods on Motor Function in Parkinson's Disease Patients [ identifier: NCT01615718]
  • Safety, Tolerability and Efficacy Assessment of Dynacirc CR in Parkinson's Disease (STEADY-PD) [ identifier: NCT00909545]

Parkinson's Disease Biomarkers Program (PDBP)

  • Unbiased Approaches to Novel Biomarker Discovery in Parkinson's Disease [NINDS Grant U01NS082134-01]
  • Biomarkers for Early Intervention in Parkinson Disease [NINDS Grant U01NS082157-01]
  • Multimodal MRI Markers of Nigrostriatal Pathology in Parkinson's Disease [NINDS Grant U01NS082151-01]
  • Large Scale Biomarker Discovery and Validation for Parkinson's Disease [NINDS Grant U01NS082137-01]
  • Diagnostic and Prognostic Biomarkers for Parkinson's Disease [NINDS Grant U01NS082148-01]
  • Johns Hopkins Medicine Biomarker Discovery in Parkinson's Disease [NINDS Grant U01NS082133-01]
  • LRRK2 and Other Novel Exosome Proteins in Parkinson's Disease [NINDS Grant U18NS082132-01]
  • Development of Lewy Bodies Biofluid Signatures by Targeted Proteomics [NINDS Grant U18NS082140-01]
  • Analytic Methods for Determining Multimodal Biomarkers for Parkinson's Disease [NINDS Grant U18NS082143-01]
  • Non-invasive Markers of Neurodegeneration in Movement Disorders [NINDS Grant R01NS075012-02]
  • Serotonin and Amyloidopathy [NINDS Grant 1R56NS082941-01A1]
  • Evaluation of glucocerebrosidase pathway biomarkers in Parkinson Disease (U01) [NINDS Grant U01NS094148-01]

Spinal Cord Injury

  • Training Programs to Improve Outcomes for Individuals with Spinal Cord Injury (University of Pittsburgh) [ identifier: NCT010807728 ]
  • Study of Riluzole in Patients with Acute Spinal Cord Injury The Methodist Hospital System Ralph Frankowski [ identifier: NCT01282242]

Spinal Muscular Atrophy

  • Spinal Muscular Atrophy (SMA) Biomarkers Study in the Immediate Postnatal Period of Development [ identifier: NCT01736553] (from NeuroNEXT Network)


  • MR WITNESS: A Study of Intravenous Thrombolysis With Alteplase in MRI-Selected Patients [ identifier: NCT01282242]
  • Stroke Hyperglycemia Insulin Network Effort (SHINE) Trial [ Identifier: NCT01369069]
  • Thrombolysis in Pediatric Stroke (TIPS) [ Identifier: NCT01591096]
  • High-Dose Deferoxamine in Intracerebral Hemorrhage (HI-DEF) [ Identifier: NCT01662895]
  • Carotid Revascularization for Primary Prevention of Stroke (CREST-2) [ Identifier: NCT02089217]
  • The SUCCEED Trial of Secondary Stroke Prevention [ NCT01763203]
  • Minimally Invasive Surgery Plus Rt-PA for ICH Evacuation Phase III (MISTIE III) [ identifier: NCT01827046]
  • Safety Evaluation of 3K3A-APC in Ischemic Stroke (RHAPSODY) [ Identifier: NCT02222714]
  • Intracerebral Hemorrhage Deferoxamine Trial - iDEF Trial [ Identifier: NCT02175225]
  • Endovascular Therapy Following Imaging Evaluation for Ischemic Stroke 3 (DEFUSE 3) [ identifier: NCT02586415]
  • Primary Prevention of Stroke in Children With Sickle Cell Disease in Sub-Saharan Africa II (SPRING) [ identifier: NCT02560935]
  • Telerehabilitation in the Home Versus Therapy In-Clinic for Patients With Stroke [ identifier: NCT02360488]

Traumatic Brain Injury

  • Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) [ identifier: NCT01565551]
  • National Brain and Tissue Resource for Parkinson's Disease and Related Disorders [ identifier: 5U24NS072026-03 ]
  • Minimally Invasive Surgery Plus Rt-PA for ICH Evacuation Phase III [ identifier: NCT01827046]
  • Futility Study of Deferoxamine Mesylate in Intracerebral Hemorrhage [ identifier: NCT01662895]
  • Frontal Lobe Neuroimaging as a Biomarker of Chronic Traumatic Encephalopathy [NINDS Grant 1F31NS081957-01 ]
  • The Impact of Concussive and Sub-Concussive Blows On Brain Network Activity [NINDS Grant 1R15NS081691-01 ]
  • Managing Severe TBI Without ICP Monitoring - Guidelines Development and Testing [NINDS Grant 3R01NS080648-02S1 ]
  • In Vivo Measurement of Brain Biomechanics [NINDS Grant 2R01NS055951-05 ]
  • Multiple Medical Therapies for Pediatric TBI; Comparative Effectiveness Approach [NINDS Grant 1U01NS081041-01A1 ]
  • Brain Injury Due to Soccer Heading and Opportunities for Its Mitigation [NINDS Grant 1R01NS082431-01 ]
  • The Cerebellum's Contribution to Working Memory Following Traumatic Brain Injury [NINDS Grant 1F31NS080574-01A1 ]
  • Phase 2 Pediatric Autologous BMMNC For Severe TBI [NINDS Grant 1R01NS077963-01A1 ]
  • Neurosensory Assessments of Concussion [NINDS Grant 1R21NS081411-01A1 ]
  • Default Mode Interference and Working Memory in Mild Traumatic Brain Injury [NINDS Grant 1F31NS081984-01A1 ]
  • A trial of intracranial-pressure monitoring in traumatic brain injury [NINDS Grant 1 R01 NS080648-01]
  • Multimodality image-based assessment system for traumatic brain injury [NINDS Grant 1 R41 NS081792-01]
  • Multiplexed Multiband MR at 7T: Studies of mild Traumatic Brain Injury [NINDS Grant 1R01NS081772-01]
  • Measuring Material Properties of the Human Brain in vivo [NINDS Grant 1R21NS078607-01A1]
  • Brain injury due to soccer heading and opportunities for its mitigation [NINDS Grant 1R01NS082432-01]
  • Neurosensory Assessments of Concussion [NINDS Grant 1 R21 NS081411-01A1]
  • Default Mode Interference and Working Memory in Mild Traumatic Brain Injury [NINDS Grant 1 F31 NS081984-01A1]
  • Transforming Research and Clinical Knowledge in Traumatic Brain Injury [NINDS Grant 1 U01 NS086090-01]
  • Quantitative MRI and 1H-MRS in Traumatic Brain Injury [NINDS Grant 2 R01 NS039135-11A1]
  • Imaging and Biomarkers in Adolescents Cleared for Return to Play After Concussion [NINDS Grant 1 R21 NS086714-01 ]
  • Cortical GABA in pediatric sports concussion [NINDS Grant 1 R03 NS086580-01]
  • Examining the role of neuronal injury in concussion-related cognitive dysfunction [NINDS Grant 1 F32 NS083284-01A1]
  • CTE and Posttraumatic Neurodegeneration: Neuropathology and Ex Vivo Imaging [NINDS Grant 1 U0 1NS086659-01 ]
  • Neuropathology of CTE and Delayed Effects of TBI: Toward In-Vivo Diagnostics [NINDS Grant 1 U01 NS086625-01]
  • Impact of Aging on the Immune Response to Traumatic Brain Injury [NINDS Grant 3R01NS077913-02S1]
  • Noninvasive Determination of Intracranial Pressure in Pediatric Patients [NINDS Grant 1 R21 NS084264-01A1]
  • iTAKL: Imaging Telemetry And Kinematic modeLing in youth football [NINDS Grant 1 R01 NS082453-01A1]
  • Addition of Pediatric TBI Data to FITBIR [NINDS Grant 1 R03 NS087984-01 ]
  • Traumatic Brain Injury Data for FITBIR Informatics system [NINDS Grant 1 R03 NS088014-01]
  • Adding Legacy Clinical Data to the Federal Interagency Traumatic Brain Injury (FITBIR) Informatics System
    [NINDS Grant 1 R03 NS088021-01]
  • White Matter Damage in Subconcussive Blast Exposure [NINDS Grant 1 R01 NS086885-01A1]
  • Measuring Biomarkers in Various Biological Compartments after TBI [NINDS Grant 1 R03 NS087350-01A1]
  • Somatosensory Processing-Assessing Youth Sport-Related Concussion and Recovery [NINDS Grant 1R21HD080378-01]
  • Evaluation of Spot Light: A concussion injury management app for youth sports [NINDS Grant 1R21HD080377-01]
  • Eye movement dynamics: a rapid objective involuntary measure of concussion/mTBI [NINDS Grant 1R21DC013974-01]


  • Preterm Erythropoietin Neuroprotection Trail (PENUT Trial) [Clinical identifier: NCT01378273]
  • Early Biomarkers of Autism Spectrum Disorders in Infants with Tuberous Sclerosis [NINDS Grant 5U01NS082320-02 ]