CDE Detailed Report

Disease: content
Sub-Domain: Laboratory Tests and Biospecimens/Biomarkers
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CDE ID CDE Name Variable Name Definition Short Description Additional Notes (Question Text) Permissible Values Description Data Type Disease Specific Instructions Disease Specific Reference Population Classification (e.g., Core) Version Number Version Date CRF Name (CRF Module / Guideline) Sub Domain Name Domain Name Size Input Restrictions Min Value Max Value Measurement Type External Id Loinc External Id Snomed External Id caDSR External Id CDISC
C10890 Resting energy expenditure measurement RestEnrgyExpendMeasr Resting Energy Expenditure (REE) is a measure of the calories (energy) burned to maintain bodily functions in the alert, resting (physically inactive) state Resting Energy Expenditure (REE) is a measure of the calories (energy) burned to maintain bodily functions in the alert, resting (physically inactive) state Numeric Values

Typically, the BMR is measured in a research setting in a metabolic unit whereas measuring REE is more feasible in the outpatient setting. Both REE and BMR can be measured directly using indirect calorimetry or estimated from standard predictive equations. Indirect calorimetry determines the amount of oxygen (O2) consumed and carbon dioxide (CO2) produced using controlled analytic methods. The results will indicate the number of total calories expended per unit time and the RQ (respiratory quotient), which is in indication of the predominant type of substrate oxidized (fat or carbohydrate). Many equations have been developed and validated against indirect calorimetry to estimate either REE or BMR based on easy-to-measure clinical factors such as height, weight, age, sex, lean body mass, and fat mass in varying combinations. The Harris-Benedict equation is the most widely used equation of this type in dietetic practice.

Harris JA, Benedict FG. A biometric study of human basal metabolism. Proc Natl Acad Sci USA. 1918; 4(12): 370&#8211;373.<br /><br />Harris JA, Benedict FG. A Biometric Study of Basal Metabolism in Man. (Carnegie Institute of Washington Publication 279.) Washington, DC: Carnegie Institute of Washington, 1919. Adult Exploratory 3.00 2013-07-22 16:57:17.79 Resting Energy Expenditure Laboratory Tests and Biospecimens/Biomarkers Assessments and Examinations

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C10891 Basal metabolic rate BaslMetblcRate Basal Metabolic Rate (BMR) is the Resting Energy Expenditure (REE) measured upon awakening after an overnight fast Basal Metabolic Rate (BMR) is the Resting Energy Expenditure (REE) measured upon awakening after an overnight fast Numeric Values

Typically, the BMR is measured in a research setting in a metabolic unit whereas measuring REE is more feasible in the outpatient setting. Both REE and BMR can be measured directly using indirect calorimetry or estimated from standard predictive equations. Indirect calorimetry determines the amount of oxygen (O2) consumed and carbon dioxide (CO2) produced using controlled analytic methods. The results will indicate the number of total calories expended per unit time and the RQ (respiratory quotient), which is in indication of the predominant type of substrate oxidized (fat or carbohydrate). Many equations have been developed and validated against indirect calorimetry to estimate either REE or BMR based on easy-to-measure clinical factors such as height, weight, age, sex, lean body mass, and fat mass in varying combinations. The Harris-Benedict equation is the most widely used equation of this type in dietetic practice.

Harris JA, Benedict FG. A biometric study of human basal metabolism. Proc Natl Acad Sci USA. 1918; 4(12): 370&#8211;373.<br /><br />Harris JA, Benedict FG. A Biometric Study of Basal Metabolism in Man. (Carnegie Institute of Washington Publication 279.) Washington, DC: Carnegie Institute of Washington, 1919. Adult Exploratory 3.00 2013-07-22 16:57:17.79 Resting Energy Expenditure Laboratory Tests and Biospecimens/Biomarkers Assessments and Examinations

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