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Timed 25-Foot Walk (T25-FW)
Core: Friedreich's Ataxia (FA)
Supplemental-Highly Recommended: Multiple Sclerosis (MS)
Timed 25-Foot Walk is a part of the MS Outcomes Assessments Consortium (MSOAC) Battery of tests, which is recommended as Supplemental – Highly Recommended for MS:
Timed 25 Foot Walk
9-Hole Peg Test
Sloan Low Contrast Letter Acuity
Symbol Digit Modalities Test
Each of the measures in the Consortium can be used individually as primary or secondary endpoints.
Supplemental: Amyotrophic Lateral Sclerosis (ALS)
Short Description of Instrument
Construct Measure: Quantitative mobility and leg function performance test.
Generic vs. disease specific: Generic.
Means of administration: In person by a trained examiner, who need not be a physician or nurse.
Intended respondent: Administrator.
# of items: N/A.
# of subscales and names of sub-scales: N/A.
# of items per sub-scale: N/A.
Comments/Special Instructions
Scoring: Score for the Timed 25-foot Walk (T25-FW) is the average of the two completed trials. This score can be used individually or used as part of the MSOAC Battery composite score. The T25-FW can also be scored to assess walking speed by dividing 25 by time, which yield feet per second. If at the upper end of the disability spectrum, this may be the preferred method.
Background: The T25-FW is a quantitative mobility and leg function performance test based on a timed 25-walk. It is the first component of the MSOAC Battery to be administered at each visit. The patient is directed to one end of a clearly marked 25-foot course and is instructed to walk 25 feet as quickly as possible, but safely. The time is calculated from the initiation of the instruction to start and ends when the patient has reached the 25-foot mark. The task is immediately administered again by having the patient walk back the same distance. Patients may use assistive devices when doing this task.
Strengths/Weaknesses: Gait speed in general has been demonstrated to be a useful and reliable functional measure of walking ability. The T25-FW is similar to the Ambulation Index, but while the T25-FW measures the time needed to complete the task, the AI uses a clinical rating of a performance category, and the 10MTW measures the time an individual walks 10 meters.
Psychometric Properties: The T25-FW has high inter-rater and test-retest reliability and shows evidence of good concurrent validity.
Administration: Administration time will vary depending upon the ability of the patient, but should be approximately 1-5 minutes. When administering the 25-FTW, patients are allowed to use assistive devices (canes, crutches, walkers). In addition special instructions are provided for scoring patients who are unable to complete the assessment due to severity of impairment.
Cohen JA, Krishnan AV, Goodman AD, Potts J, Wang P, Havrdova E, Polman C, Rudick RA. The clinical meaning of walking speed as measured by the timed 25-foot walk in patients with multiple sclerosis. JAMA Neurol. 2014;71(11):1386-1393.
Kaufman M, Moyer D, Norton J. The significant change for the Timed 25-foot Walk in the multiple sclerosis functional composite. Mult Scler. 2000;6(4):286-290.
Motl RW, Cohen JA, Benedict R, Phillips G, LaRocca N, Hudson LD, Rudick R; Multiple Sclerosis Outcome Assessments Consortium. Validity of the timed 25-foot walk as an ambulatory performance outcome measure for multiple sclerosis. Mult Scler. 2017 Apr;23(5):704-710.


Document last updated April 2020