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ALS Depression Inventory (ADI-12)
Please email the author for information about obtaining the instrument: Dr. Andrea Kuebler,
Supplemental: Amyotrophic Lateral Sclerosis (ALS) and Mitochondrial Disease (Mito)
Short Description of Instrument
The Amyotrophic Lateral Sclerosis Depression Inventory 12 (ADI-12) is a 12 item self-rated questionnaire designed to rate depressive disorders in patients who suffer from ALS. This test describes mood, anhedonia, and energy but does not refer to the motor related symptoms seen in ALS.
The ADI-12 was validated against the structured clinical interview for DSM-IV (SCID), as the gold standard for diagnosis of depression.
Scoring and Psychometric Properties
Scoring: Scores range from 12 (the best possible) to 48 (worst possible). Scores between 23 and 29 indicate mild depression and scores over 30 indicate severe depression.
Strengths: Considers the possibility of progressive physical impairment by excluding statements that require motor functions; brief and high validity; highly correlated with BDI-II.
Weaknesses: Hard to distinguish from apathy.
Key Reference:
Hammer EM, Haecker S, Hautzinger M, Meyer TD, Kuebler A. Validity of the ALS-Depression-Inventory (ADI-12)--a new screening instrument for depressive disorders in patients with amyotrophic lateral sclerosis. J Affect Disord. 2008 Jul;109(1-2):213-9.
Additional Reference:
Atassi N, Cook A, Pineda CM, Yerramilli-Rao P, Pulley D, Cudkowicz M. Depression in amyotrophic lateral sclerosis. Amyotroph Lateral Scler. 2011 Mar;12(2):109-12.
Document last updated March 2024