CDE Detailed Report

Disease: content
Subdomain Name: Other Clinical Data
CRF: welcome

Displaying 151 - 175 of 175
CDE ID CDE Name Variable Name Definition Short Description Question Text Permissible Values Description Data Type Disease Specific Instructions Disease Specific Reference Population Classification (e.g., Core) Version Number Version Date CRF Name (CRF Module / Guidance) Subdomain Name Domain Name Size Input Restrictions Min Value Max Value Measurement Type External Id Loinc External Id Snomed External Id caDSR External Id CDISC
C17758 Striatum atrophy hypothalamus atrophy severity result StrAtrophyHypoAtrophySevReslt Quantitative result of the severity of atrophy located in the hypothalamus Quantitative result of the severity of atrophy located in the hypothalam Present Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Alphanumeric

Striatum atrophy

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Single Pre-Defined Value Selected

C15056 Brain atrophy substantia nigra pars reticulata neuronal loss severity result BrAtSubNiParsRetNeuLosSevReslt Quantitative result of the severity of neuronal loss in the pars reticulata Quantitative result of the severity of neuronal loss in the pars reticulat Yes, neuronal loss Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Alphanumeric

Substantia nigra

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C15067 Brain atrophy pontine nuclei globosum neuronal tangles status BrAtPontineNucGloNeurTanStat Status of globosum neuronal tangles (GNT) in the pontine nuclei Status of globosum neuronal tangles (GNT) in the pontine nucle Pontine nuclei Globosum neuronal tangles (GNT) Absent;Present Absent;Present Alphanumeric

Pons: Neuronal loss

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C14975 Brain lobe examination anatomic site BrainLobeAExamAntmicSite Anatomic site examined in the brain Anatomic site examined in the brain If yes Frontal;Parietal;Temporal;Occipital Frontal;Parietal;Temporal;Occipital Alphanumeric

No additional instructions

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C15099 Cortical laminar necrosis single or multiple vascular territories name CortLaNecSingMultiVasTerName Name of the vascular territories where cortical laminar necrosis occurs Name of the vascular territories where cortical laminar necrosis occurs Vascular territories (ACA anterior cerebral artery; MCA middle cerebral artery; PCA posterior cerebral artery) ACA;MCA;PCA;Combined ACA=anterior cerebral artery;MCA=middle cerebral artery;PCA=posterior cerebral artery; Alphanumeric

No additional instructions

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C15035 Brain atrophy neuronal loss fibrillary astrocytosis caudate nucleus anatomic site BrAtNeLosFibAstCauNuAntmicSite Anatomic site in the caudate nucleus (CN) where neuronal loss and/or fibrillary astrocytosis is/are present Anatomic site in the caudate nucleus (CN) where neuronal loss and/or fibrillary astrocytosis is/are present Is there evidence of neuronal loss and fibrillary astrocytosis? (caudate nucleus[CN], putamen, globus pallidus and nucleus accumbens Head, rostral, medial half;Head, rostral, lateral half;Head, caudal;Body;Tail Head, rostral, medial half;Head, rostral, lateral half;Head, caudal;Body;Tail Alphanumeric

No additional instructions

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C08148 Neuropath specimen identifier number NeuropthSpecmnIDNum Unique identification number given to the neuropathology specimen Unique identification number given to the neuropathology specimen Neuropath ID Alphanumeric

No additional instructions

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C17764 Striatum atrophy red nucleus atrophy severity result StrAtrophyRedNuAtrophySevReslt Quantitative result of the severity of atrophy located in the red nucleus Quantitative result of the severity of atrophy located in the red nucleu Present Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Alphanumeric

Striatum atrophy

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C08162 National Institute on Aging (NIA) or Reagan Institute neuropathological criteria scale NIAReaganInNeuropathCritScale National Institute on Aging (NIA)/Reagan Institute neuropathological criteria used to determine the likelihood of dementia being due to Alzheimer's disease. National Institute on Aging (NIA)/Reagan Institute neuropathological criteria used to determine the likelihood of dementia being due to Alzheimer's disease. NIA/Reagan Institute neuropathological criteria likelihood of dementia being due to Alzheimer disease (AD) Low likelihood of dementia being due to Alzheimer's disease;Intermediate likelihood of dementia being due to Alzheimer's disease;High likelihood of dementia being due to Alzheimer's disease;Criteria not met;Not assessed;Not available Low likelihood of dementia being due to Alzheimer's disease;Intermediate likelihood of dementia being due to Alzheimer's disease;High likelihood of dementia being due to Alzheimer's disease;Criteria not met;Not assessed;Not available Alphanumeric

No additional instructions

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C18995 Brain atrophy thalamus neuronal loss nuclei other text BrAtThalamusNeurLossNucOTH The free-text field related to 'Brain atrophy thalamus neuronal loss nuclei name' specifying other text. Name of the nuclei in the thalamus involved in the neuronal loss The free-text field related to 'Brain atrophy thalamus neuronal loss nuclei name' specifying other text. Name of the nuclei in the thalamus involved in the neuronal loss Other, specify Alphanumeric

No additional instructions

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C15078 Brain atrophy cerebellum cortical neuronal loss in effective layer severity result BrAtCerCortNeuLosEffLaSevReslt Quantitative result of the severity of cortical neuronal loss in the effective layer of the cerebellum Quantitative result of the severity of cortical neuronal loss in the effective layer of the cerebellum Yes, neuronal loss Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Alphanumeric

Cerebellum; Cortical neuronal loss

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C14986 Brain atrophy striatum head of caudate nucleus severity result BrAtStrCauNucHeadSevReslt Quantitative result of the severity of atrophy located in the head of the caudate nucleus (CN) (at the level where the anterior limb of the internal capsule [ALIC] joins with the basal white matter). Quantitative result of the severity of atrophy located in the head of the caudate nucleus (CN) (at the level where the anterior limb of the internal capsule [ALIC] joins with the basal white matter). Head of the CN Mild 1+;Moderate 2+;Severe3+;Very severe 4+ Mild 1+;Moderate 2+;Severe3+;Very severe 4+ Alphanumeric

Striatum atrophy: At the level where the anterior limb of the internal capsule (ALIC) joins with the basal white matter:atrophy

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C15110 Atherosclerotic luminal stenosis percentage range AtheroLuminStenPercentRange Range for the estimated luminal stenosis percentage if stenotic vascular changes (of the circle of Willis) Range for the estimated luminal stenosis percentage if stenotic vascular changes (of the circle of Willis) Yes, stentoic Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Mild 1+=up to 30% stenosis;Moderate 2+=up to 50% stenosis;Severe 3+=up to 8-% stenosis;Very severe 4+=apparent occlusion Alphanumeric

This question is answered only if "Yes stenotic" is answered for "Are there atherosclerotic, either non-stenotic or stenotic vascular changes (of the circle of Willis)?"

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C15046 Brain atrophy thalamus neuronal loss nuclei severity result BrAtThalamusNeurLosNucSevReslt Quantitative result of the severity of neuronal loss in thalamic nuclei Quantitative result of the severity of neuronal loss in thalamic nuclei Yes, neuronal loss Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Alphanumeric

To be answered for each nuclei name

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C08177 Hemorrhage indicator HemrrhgInd Indicator of the presence of cerebral hemorrhages, regardless of size in any region of the brain Indicator of the presence of cerebral hemorrhages, regardless of size in any region of the brain Are there single or multiple hemorrhages? Yes;No;Unknown;Not assessed Yes;No;Unknown;Not assessed Alphanumeric

No additional instructions

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C15089 Cortical infarcts single or multiple event category CorInfarcSingMultiEventCat Category of the cortical microinfarcts Category of the cortical microinfarcts If yes Single;Multiple Single;Multiple Alphanumeric

No additional instructions

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C15025 Brain atrophy striatum cerebellum status BrAtStriatumCerebellumStat Status of cerebellum atrophy in the striatum Status of cerebellum atrophy in the striatu Cerebellum atrophy Absent;Present Absent;Present Alphanumeric

No additional instructions

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C17759 Striatum atrophy thalamus atrophy status StrAtrophyThalamusAtrophyStat Status of atrophy in the thalamus Status of atrophy in the thalamu Thalamus atrophy Absent;Present Absent;Present Alphanumeric

Striatum atrophy

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C15057 Brain atrophy substantia nigra Lewy body containing neurons and Lewy neurites status BrAtSubNigraLeBodyLeNeurStat Status of lewy-body containing neurons (LBCN) and lewy neurites (LN) in the substantia nigra Status of lewy-body containing neurons (LBCN) and lewy neurites (LN) in the substantia nigr Lewy body containing neurons (LBCN) and Lewy neurites (LN) Absent;Present Absent;Present Alphanumeric

Substantia nigra

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C15068 Brain atrophy pontine nuclei globosum neuronal tangles (GNT) severity result BrAtPontNucGloNeurTanSevReslt Quantitative result of the severity of globosum neuronal tangles in the pontine nuclei Quantitative result of the severity of globosum neuronal tangles in the pontine nucle Yes, neuronal loss Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Alphanumeric

Pons: Neuronal loss

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C14976 Brain atrophy surface severity result BrainAtrophySurfSevReslt Quantitative result of the severity of cerebral atrophy on external brain surface Quantitative result of the severity of cerebral atrophy on external brain surface Present 0;1+/4+;2+/4+;3+/4+;4+/4+ 0=None;1+/4+=Mild;2+/4+=Moderate;3+/4+=Severe;4+/4+=Very severe Alphanumeric

This question is answered if "Present" is answered for "On gross examination of the external surface of the brain, cerebral atrophy". This question is answered for each of the brain anatomic sites.

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C15100 Cortical laminar necrosis single or multiple text CortLaminarNecSingMultiTxt The text description of the cortical laminar necrosis The text description of the cortical laminar necrosis Describe Alphanumeric

Answer for each vascular territory and event category

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C15036 Brain atrophy neuronal loss and fibrillary astrocytosis pontes griseum or gray matter caudo-lenticular bridges anatomic site BrAtNeLosFibAstroPonAntmicSite Anatomic site in the pontes griseum or gray matter caudo-lenticular bridges where neuronal loss and/or fibrillary astrocytosis is/are present Anatomic site in the pontes griseum or gray matter caudo-lenticular bridges where neuronal loss and/or fibrillary astrocytosis is/are present Pontes griseum or gray matter caudo-lenticular bridges Dorsal half;Ventral half Dorsal half;Ventral half Alphanumeric

No additional instructions

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C08149 Diagnosis final clinical death type DiagnosFinalClinDeathTyp Physician's final clinical diagnosis for the participant/subject Physician's final clinical diagnosis for the participant/subject FINAL CLINICAL DIAGNOSIS BEFORE DETAH Multiple system atrophy;Progressive supranuclear palsy;Corticobasal degeneration;Other, specify;Chorea gravidarum;Dentato-rubro-pallido-luysian atrophy (DRPLA), with genetically confirmed expansion of CAG repeats;Dentato-rubro-pallido-luysian atrophy (DRPLA), without genetically confirmed expansion of CAG repeats;Fragile X syndrome with genetically confirmed expansion of CGG repeats;Fragile X syndrome without genetically confirmed expansion of CGG repeats;Friedreich ataxia with genetically confirmed expansion of GAA repeats;Friedreich ataxia without genetically confirmed expansion of GAA repeats;Frontotemporal lobar degeneration;Hepatolenticular degeneration or Wilson disease;Huntington disease with genetically confirmed expansion of HD-IT15 CAG repeats;Huntington disease without genetically confirmed expansion of HD-IT15 CAG repeats;Huntington disease-like 2 genetically confirmed expansion of trinucleotide repeats;Huntington disease-like without genetically confirmed expansion of trinucleotide repeats;Kennedy disease with genetically confirmed expansion of CAG repeats;Kennedy disease without genetically confirmed expansion of CAG repeats;Pantothenate kinase-associated neurodegeneration (Hallervorden-Spatz syndrome);Senile chorea or vascular chorea;Spinocerebellar ataxia with genetically confirmed expansion of either CAG or CTG repeats;Spinocerebellar ataxia without genetically confirmed expansion of either CAG or CTG repeats;Subacute sclerosing panencephalitis;Sydenham chorea;Tardive dyskinesia;Neuroacanthocytosis;Pick disease Multiple system atrophy;Progressive supranuclear palsy;Corticobasal degeneration;Other, specify;Chorea gravidarum;Dentato-rubro-pallido-luysian atrophy (DRPLA), with genetically confirmed expansion of CAG repeats;Dentato-rubro-pallido-luysian atrophy (DRPLA), without genetically confirmed expansion of CAG repeats;Fragile X syndrome with genetically confirmed expansion of CGG repeats;Fragile X syndrome without genetically confirmed expansion of CGG repeats;Friedreich ataxia with genetically confirmed expansion of GAA repeats;Friedreich ataxia without genetically confirmed expansion of GAA repeats;Frontotemporal lobar degeneration;Hepatolenticular degeneration or Wilson disease;Huntington disease with genetically confirmed expansion of HD-IT15 CAG repeats;Huntington disease without genetically confirmed expansion of HD-IT15 CAG repeats;Huntington disease-like 2 genetically confirmed expansion of trinucleotide repeats;Huntington disease-like without genetically confirmed expansion of trinucleotide repeats;Kennedy disease with genetically confirmed expansion of CAG repeats;Kennedy disease without genetically confirmed expansion of CAG repeats;Pantothenate kinase-associated neurodegeneration (Hallervorden-Spatz syndrome);Senile chorea or vascular chorea;Spinocerebellar ataxia with genetically confirmed expansion of either CAG or CTG repeats;Spinocerebellar ataxia without genetically confirmed expansion of either CAG or CTG repeats;Subacute sclerosing panencephalitis;Sydenham chorea;Tardive dyskinesia;Neuroacanthocytosis;Pick disease Alphanumeric

No additional instructions

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Multiple Pre-Defined Values Selected

C17765 Striatum atrophy hydrocephalus lateral ventricle severity result StrAtrophyHydroLatVentSevReslt Quantitative result of the severity of hydrocephalus located in the lateral ventricle Quantitative result of the severity of hydrocephalus located in the lateral ventricl Lateral ventricle None;Mild;Moderate;Severe;Not assessed;Not available None;Mild;Moderate;Severe;Not assessed;Not available Alphanumeric

Striatum atrophy; Hydrocephalus

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CSV