CDE Detailed Report

Disease: content
Subdomain Name: Other Clinical Data
CRF: welcome

Displaying 51 - 100 of 175
CDE ID CDE Name Variable Name Definition Short Description Question Text Permissible Values Description Data Type Disease Specific Instructions Disease Specific Reference Population Classification (e.g., Core) Version Number Version Date CRF Name (CRF Module / Guidance) Subdomain Name Domain Name Size Input Restrictions Min Value Max Value Measurement Type External Id Loinc External Id Snomed External Id caDSR External Id CDISC
C15054 Brain atrophy substantia nirgra pars compacta neuronal loss severity result BrAtSubNiParsCoNeuLossSevReslt Quantitative result of the severity of neuronal loss in the pars compacta Quantitative result of the severity of neuronal loss in the pars compact Yes, neuronal loss Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Alphanumeric

Substantia nigra

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Single Pre-Defined Value Selected

C08173 Ischemic hemorrhagic or vascular pathology indicator IschHemVasclPathInd Indicator of the presence of ischemic, hemorrhagic, or vascular pathology Indicator of the presence of ischemic, hemorrhagic, or vascular pathology Are there ischemic or hemorrhagic changes? Yes;No;Unknown;Not assessed Yes;No;Unknown;Not assessed Alphanumeric

If 'No' is answered for ischemic or hemorrhagic changes, skip to question 43.

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C15086 Ischemic or hemorrhagic changes event category IschHemChangesEventCat Category of the ischemic or hemorrhagic changes Category of the ischemic or hemorrhagic changes Yes, present Single;Multiple Single;Multiple Alphanumeric

No additional instructions

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C17765 Striatum atrophy hydrocephalus lateral ventricle severity result StrAtrophyHydroLatVentSevReslt Quantitative result of the severity of hydrocephalus located in the lateral ventricle Quantitative result of the severity of hydrocephalus located in the lateral ventricl Lateral ventricle None;Mild;Moderate;Severe;Not assessed;Not available None;Mild;Moderate;Severe;Not assessed;Not available Alphanumeric

Striatum atrophy; Hydrocephalus

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Single Pre-Defined Value Selected

C15022 Brain atrophy nucleus coeruleus appearance grade BrAtNucleusCoeruleusAppGrade Grade of pigmentation of the nucleus coeruleus Grade of pigmentation of the nucleus coeruleus Nucleus coeruleus Well pigmented;Darker 1+;Darker 2+;Darker 3+;Very severe 4+ (Darker);Paler 1+;Paler 2+;Paler 3+;Very severe 4+ (Paler) Well pigmented;Darker 1+;Darker 2+;Darker 3+;Very severe 4+ (Darker);Paler 1+;Paler 2+;Paler 3+;Very severe 4+ (Paler) Alphanumeric

Striatum atrophy

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C15033 Brain atrophy amygdala neuronal loss indicator BrAtAmygdalaNeurLossInd Indicator of neuronal loss in the amygdala Indicator of neuronal loss in the amygdal Amygdala Neuronal Loss No neuronal loss;Yes neuronal loss No neuronal loss;Yes neuronal loss Alphanumeric

No additional instructions

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Single Pre-Defined Value Selected

C06005 Data collected date and time DataCollDateTime Date (and time, if applicable and known) the data were collected. This may be the date/time a particular examination or procedure was performed Date (and time, if applicable and known) the data were collected. This may be the date/time a particular examination or procedure was performe Date form completed Date or Date & Time

Record the date/time according to the ISO 8601, the International Standard for the representation of dates and times (http://www.iso.org/iso/home.html). The date/time should be recorded to the level of granularity known (e.g., year, year and month, complete date plus hours and minutes, etc.).

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C15065 Brain atrophy pons neuronal loss indicator BrAtPonsNeurLossInd Indicator of neuronal loss in the pons Indicator of neuronal loss in the pon Pons Neuronal loss No neuronal loss;Yes neuronal loss No neuronal loss;Yes neuronal loss Alphanumeric

Pons: Neuronal loss

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Single Pre-Defined Value Selected

C14973 Microscopical examination blocks source MicroExamBlocksSource The source of blockage based on microscopical examination of brain The source of blockage based on microscopical examination of brain Microscopical examination Source of blocks Not available;Other, specify;Bilateral;Left half of brain;Right half of brain Not available;Other, specify;Bilateral;Left half of brain;Right half of brain Alphanumeric

Indicate the parts selected for evaluation

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C15097 Single or multiple hemorrhages description text SingMultiHemDescriptTxt The text description of the hemorrhages The text description of the hemorrhages Describe Alphanumeric

Answer for each vascular territory and event category

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Free-Form Entry

C18996 Silver staining methods other text SilverStainMethdsOTH The free-text field related to 'Silver staining methods type' specifying other text. Silver staining methods used for identifying Alzheimer disease type changes The free-text field related to 'Silver staining methods type' specifying other text. Silver staining methods used for identifying Alzheimer disease type changes Other, specify Alphanumeric

Answer for each type of microscopic brain abnormality

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C15044 Brain atrophy thalamus neuronal loss severity result BrAtThalamusNeurLossSevReslt Quantitative result of the severity of neuronal loss in the thalamus Quantitative result of the severity of neuronal loss in the thalamus Yes, neuronal loss Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Alphanumeric

This question is answered if "Yes, neuronal loss" is answered for 'Thalamus: neuronal loss"

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Single Pre-Defined Value Selected

C08158 Brain weight measurement BrainWgtMeasr Weight of the participant's/subject's brain in grams Weight of the participant's/subject's brain in grams Brain weight-Part weighed Numeric Values

This value should be recorded in grams (g) for all brain tissue weighed

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gram
C15076 Brain atrophy cerebellum cortical neuronal loss in receptive layer severity result BrAtCerCortNeuLosRecLaSevReslt Quantitative result of the severity of cortical neuronal loss in the receptive layer of the cerebellum Quantitative result of the severity of cortical neuronal loss in the receptive layer of the cerebellum Yes, neuronal loss Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Alphanumeric

Cerebellum; Cortical neuronal loss

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Single Pre-Defined Value Selected

C14984 Brain atrophy coronal sections amygdala severity result BrAtCorSecAmygdalaSevReslt Quantitative result of the severity of amygdala atrophy in the coronal sections of the brain Quantitative result of the severity of amygdala atrophy in the coronal sections of the brain Present Mild 1+;Moderate 2+;Severe3+;Very severe 4+ Mild 1+;Moderate 2+;Severe3+;Very severe 4+ Alphanumeric

Coronal slices: On gross examination of the coronal sections

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C15108 Diagnoses final clinicopathological severity scale DiagnosFinClinicopathSevScale Scale of the severity or intensity of the diagnosis Scale of the severity or intensity of the diagnosis Final Clinicopathological Diagnosis Mild;Moderate;Severe Mild;Moderate;Severe Alphanumeric

Only answered if "Encephalopathy of hypoxic-ischemic type, acute", "Alzheimer changes", or "Status cribrosus and lacunaris" are answered for Final Clinicopathological diagnoses

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Single Pre-Defined Value Selected

C17757 Striatum atrophy hypothalamus atrophy status StrAtrophyHypothAtrophyStat Status of atrophy in the hypothalamus Status of atrophy in the hypothalamu Hypothalamus atrophy Absent;Present Absent;Present Alphanumeric

Striatum atrophy

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Single Pre-Defined Value Selected

C15055 Brain atrophy substantia nigra pars reticulata neuronal loss indicator BrAtSubNiParsReticNeurLosInd Indicator of neuronal loss in the pars reticulata of the substantia nigra Indicator of neuronal loss in the pars reticulata of the substantia nigr Pars reticulata Neuronal loss No neuronal loss;Yes neuronal loss No neuronal loss;Yes neuronal loss Alphanumeric

Substantia nigra

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C08175 Cortical microinfarct indicator CortclMicroinfarcInd Indicator of the presence of one or more infarcts that are detected microscopically (including "granular atrophy") and may not be grossly visible, or may appear to the naked eye as cortical granularity Indicator of the presence of one or more infarcts that are detected microscopically (including "granular atrophy") and may not be grossly visible, or may appear to the naked eye as cortical granularity Are there single or multiple cortical microinfarcts (each, <1.5cm in greatest dimension, including "granular atrophy")? Yes;No;Unknown;Not assessed Yes;No;Unknown;Not assessed Alphanumeric

Cortical microinfarcts are defined as

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C15087 Ischemic or hemorrhagic vascular territories name IschHemVasclTerritoriesName Name of the vascular territories where ischemic or hemorrhagic changes occur Name of the vascular territories where ischemic or hemorrhagic changes occur Vascular territories (ACA anterior cerebral artery; MCA middle cerebral artery; PCA posterior cerebral artery) ACA;MCA;PCA;Combined ACA=anterior cerebral artery;MCA=middle cerebral artery;PCA=posterior cerebral artery; Alphanumeric

No additional instructions

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Single Pre-Defined Value Selected

C17766 Striatum atrophy hydrocephalus third ventricle severity result StrAtrophyHydroThVentSevReslt Quantitative result of the severity of hydrocephalus located in the third ventricle Quantitative result of the severity of hydrocephalus located in the third ventricl Third ventricle None;Mild;Moderate;Severe;Not assessed;Not available None;Mild;Moderate;Severe;Not assessed;Not available Alphanumeric

Striatum atrophy; Hydrocephalus

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C15023 Brain atrophy striatum brainstem status BrAtStriatumBrainstemStat Status of brainstem atrophy in the striatum Status of brainstem atrophy in the striatu Brainstem atrophy Absent;Present Absent;Present Alphanumeric

Striatum atrophy

Kemper TL. Neuroanatomical and Neuropathological changes during aging and dementia, Second edn., Oxford University Press, New York, 1994, 3-67. Esiri MM and Morris JH. Practical approach to pathological diagnosis. In: Esiri MM, Lee VM-Y, Trojanowski JQ, eds. The neuropathology of dementia. First ed. Cambridge CB2 2RU, UK: Cambridge University Press; 2004:48-74. Adult Supplemental 3.00 2013-07-14 19:48:50.273 Neuropathology Data Form Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C15034 Brain atrophy amygdala neuronal loss severity result BrAtAmygdalaNeurLossSevReslt Quantitative result of the severity of neuronal loss in the amygdala Quantitative result of the severity of neuronal loss in the amygdal Yes, neuronal loss 1+/4+;2+/4+;3+/4+;4+/4+ 1+/4+=Mild;2+/4+=Moderate;3+/4+=Severe;4+/4+=Very severe Alphanumeric

This question is answered if 'Yes, neuronal loss' is answered for 'Amygdala neuronal loss'

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Single Pre-Defined Value Selected

C08147 Data source DataSource Source of the data provided on the case report form Source of the data provided on the case report form DATA SOURCE Participant/subject;Mother;Father;Sister;Brother;Son;Daughter;Family, specify relation;Friend;Physician;Chart/Medical record;Other, specify;Unknown;Spouse Participant/subject;Mother;Father;Sister;Brother;Son;Daughter;Family, specify relation;Friend;Physician;Chart/Medical record;Other, specify;Unknown;Spouse Alphanumeric

No additional instructions

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Multiple Pre-Defined Values Selected

C15066 Brain atrophy pons neuronal loss severity result BrAtPonsNeurLossSevReslt Quantitative result of the severity of neuronal loss in the pons Quantitative result of the severity of neuronal loss in the pons Yes, neuronal loss Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Alphanumeric

Pons: Neuronal loss

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Single Pre-Defined Value Selected

C14974 Brain atrophy surface status BrainAtrophySurfStat Status of cerebral atrophy on external surface of the brain upon gross examination Status of cerebral atrophy on external surface of the brain upon gross examination On gross examination of the external surface of the brain, cerebral atrophy Absent;Present Absent;Present Alphanumeric

No additional instructions

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Single Pre-Defined Value Selected

C15098 Cortical laminar necrosis single or multiple event category CortLaminNecSingMultiEvntCat Category of the cortical laminar necrosis Category of the cortical laminar necrosis Yes Single;Multiple Single;Multiple Alphanumeric

No additional instructions

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Single Pre-Defined Value Selected

C18997 Clinicopathology diagnosis final other text ClinicopathDiagnosFinalOTH the free-text related to 'Clinicopathology diagnosis final type' specifying other text. The participant/subject's final clinicopathological diagnosis the free-text related to 'Clinicopathology diagnosis final type' specifying other text. The participant/subject's final clinicopathological diagnosis Other, specify Alphanumeric

No additional instructions

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C15045 Brain atrophy thalamus neuronal loss nuclei name BrAtThalamusNeurLossNucName Name of the nuclei in the thalamus involved in the neuronal loss Name of the nuclei in the thalamus involved in the neuronal loss If Yes, specify nuclei that are mainly involved Motor nuclei ventral anterior;Motor nuclei ventral lateral;Centrum medianum;Limbic nuclei anterior;Limbic nuclei dorso-median;Other, specify Motor nuclei ventral anterior;Motor nuclei ventral lateral;Centrum medianum;Limbic nuclei anterior;Limbic nuclei dorso-median;Other, specify Alphanumeric

No additional instructions

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Multiple Pre-Defined Values Selected

C08160 Brain tissue weigh type BrainTissWeighedTyp Type of brain tissue weighed Type of brain tissue weighed Brain weight-Part weighed Fresh whole brain;Fixed whole brain;Fixed not available;Other;Fixed left half;Fixed right half;Fresh left half;Fresh not available;Fresh right half Fresh whole brain;Fixed whole brain;Fixed not available;Other;Fixed left half;Fixed right half;Fresh left half;Fresh not available;Fresh right half Alphanumeric

No additional instructions

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Single Pre-Defined Value Selected

C15077 Brain atrophy cerebellum cortical neuronal loss in effective layer indicator BrAtCerebCortNeurLossEffLayInd Indicator of cortical neuronal loss in the effective layer (Purkinje cells) of the cerebellum Indicator of cortical neuronal loss in the effective layer (Purkinje cells) of the cerebellum Effective layer (Purknje cells) No, neuronal loss;Yes, neuronal loss No, neuronal loss;Yes, neuronal loss Alphanumeric

Cerebellum; Cortical neuronal loss

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Single Pre-Defined Value Selected

C14985 Brain atrophy striatum status BrAtStriatumStat Status of striatum (caudate nucleus [CN], putamen, globus pallidus, and nucleus accumbens) atrophy Status of striatum (caudate nucleus [CN], putamen, globus pallidus, and nucleus accumbens) atrophy Striatum (caudate nucleus [CN], putamen, globus pallidus, and nucleus accumbens) atrophy Absent;Present Absent;Present Alphanumeric

Striatum (caudate nucleus [CN], putamen, globus pallidus, and nucleus accumbens) atrophy

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C15109 Abnormality no diagnosis type AbnrmlyNoDiagTyp The diagnosis if there is no abnormality recognized The diagnosis if there is no abnormality recognized There is no diagnostic abnormality recognized Control brain;Huntington disease, grade 0 Control brain=If without neurological and psychiatric troubles, and without HD-IT15 CAG repeat expansion;Huntington disease, grade 0=If without neurological and psychiatric troubles, but with HD-IT15 CAG repeat expansion Alphanumeric

This question is answered only if "There is no diagnostic abnormality recognized" is answered for Final clinicopathological diagnosis.

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Single Pre-Defined Value Selected

C17758 Striatum atrophy hypothalamus atrophy severity result StrAtrophyHypoAtrophySevReslt Quantitative result of the severity of atrophy located in the hypothalamus Quantitative result of the severity of atrophy located in the hypothalam Present Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Alphanumeric

Striatum atrophy

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C15056 Brain atrophy substantia nigra pars reticulata neuronal loss severity result BrAtSubNiParsRetNeuLosSevReslt Quantitative result of the severity of neuronal loss in the pars reticulata Quantitative result of the severity of neuronal loss in the pars reticulat Yes, neuronal loss Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Alphanumeric

Substantia nigra

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Single Pre-Defined Value Selected

C08176 Lacunes single or multiple indicator LacunesSingMultiInd Indicator of the presence of one or more cystic/old infarcts or hemorrhages 1-cm or less in diameter that are usually grossly identified and in the distribution of small parenchymal vessels, most often in basal ganglia, thalamus, pons, cerebellum and cerebral white matter Indicator of the presence of one or more cystic/old infarcts or hemorrhages 1-cm or less in diameter that are usually grossly identified and in the distribution of small parenchymal vessels, most often in basal ganglia, thalamus, pons, cerebellum and cerebral white matte Are there single or multiple lacunes (each > 1,5cm, but = 2c, small artery infarcts Yes;No;Unknown;Not assessed Yes;No;Unknown;Not assessed Alphanumeric

Lacunes are defined as > 1.5cm each but = 2 cm small artery infarcts.

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Single Pre-Defined Value Selected

C15088 Ischemic or hemorrhagic changes description text IschHemChangesDescriptTxt The text description of the ischemic or hemorrhagic changes The text description of the ischemic or hemorrhagic changes Describe Alphanumeric

Answer for each vascular territory and event category

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Free-Form Entry

C17767 Striatum atrophy hydrocephalus fourth ventricle severity result StrAtrophyHydroFoVentSevReslt Quantitative result of the severity of hydrocephalus located in the fourth ventricle Quantitative result of the severity of hydrocephalus located in the fourth ventricl Fourth ventricle None;Mild;Moderate;Severe;Not assessed;Not available None;Mild;Moderate;Severe;Not assessed;Not available Alphanumeric

Striatum atrophy; Hydrocephalus

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C15024 Brain atrophy striatum brainstem severity result BrAtStriatBrainstemSevReslt Quantitative result of the severity of brainstem atrophy located in the striatum Quantitative result of the severity of brainstem atrophy located in the striatu Present Mild 1+;Moderate 2+;Severe3+;Very severe 4+ Mild 1+;Moderate 2+;Severe3+;Very severe 4+ Alphanumeric

This question is answered if 'Present' is answered for 'Brainstem atrophy'

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C15035 Brain atrophy neuronal loss fibrillary astrocytosis caudate nucleus anatomic site BrAtNeLosFibAstCauNuAntmicSite Anatomic site in the caudate nucleus (CN) where neuronal loss and/or fibrillary astrocytosis is/are present Anatomic site in the caudate nucleus (CN) where neuronal loss and/or fibrillary astrocytosis is/are present Is there evidence of neuronal loss and fibrillary astrocytosis? (caudate nucleus[CN], putamen, globus pallidus and nucleus accumbens Head, rostral, medial half;Head, rostral, lateral half;Head, caudal;Body;Tail Head, rostral, medial half;Head, rostral, lateral half;Head, caudal;Body;Tail Alphanumeric

No additional instructions

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C08148 Neuropath specimen identifier number NeuropthSpecmnIDNum Unique identification number given to the neuropathology specimen Unique identification number given to the neuropathology specimen Neuropath ID Alphanumeric

No additional instructions

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C15067 Brain atrophy pontine nuclei globosum neuronal tangles status BrAtPontineNucGloNeurTanStat Status of globosum neuronal tangles (GNT) in the pontine nuclei Status of globosum neuronal tangles (GNT) in the pontine nucle Pontine nuclei Globosum neuronal tangles (GNT) Absent;Present Absent;Present Alphanumeric

Pons: Neuronal loss

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C14975 Brain lobe examination anatomic site BrainLobeAExamAntmicSite Anatomic site examined in the brain Anatomic site examined in the brain If yes Frontal;Parietal;Temporal;Occipital Frontal;Parietal;Temporal;Occipital Alphanumeric

No additional instructions

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Single Pre-Defined Value Selected

C15099 Cortical laminar necrosis single or multiple vascular territories name CortLaNecSingMultiVasTerName Name of the vascular territories where cortical laminar necrosis occurs Name of the vascular territories where cortical laminar necrosis occurs Vascular territories (ACA anterior cerebral artery; MCA middle cerebral artery; PCA posterior cerebral artery) ACA;MCA;PCA;Combined ACA=anterior cerebral artery;MCA=middle cerebral artery;PCA=posterior cerebral artery; Alphanumeric

No additional instructions

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Single Pre-Defined Value Selected

C15046 Brain atrophy thalamus neuronal loss nuclei severity result BrAtThalamusNeurLosNucSevReslt Quantitative result of the severity of neuronal loss in thalamic nuclei Quantitative result of the severity of neuronal loss in thalamic nuclei Yes, neuronal loss Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Alphanumeric

To be answered for each nuclei name

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Single Pre-Defined Value Selected

C08162 National Institute on Aging (NIA) or Reagan Institute neuropathological criteria scale NIAReaganInNeuropathCritScale National Institute on Aging (NIA)/Reagan Institute neuropathological criteria used to determine the likelihood of dementia being due to Alzheimer's disease. National Institute on Aging (NIA)/Reagan Institute neuropathological criteria used to determine the likelihood of dementia being due to Alzheimer's disease. NIA/Reagan Institute neuropathological criteria likelihood of dementia being due to Alzheimer disease (AD) Low likelihood of dementia being due to Alzheimer's disease;Intermediate likelihood of dementia being due to Alzheimer's disease;High likelihood of dementia being due to Alzheimer's disease;Criteria not met;Not assessed;Not available Low likelihood of dementia being due to Alzheimer's disease;Intermediate likelihood of dementia being due to Alzheimer's disease;High likelihood of dementia being due to Alzheimer's disease;Criteria not met;Not assessed;Not available Alphanumeric

No additional instructions

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Single Pre-Defined Value Selected

C15078 Brain atrophy cerebellum cortical neuronal loss in effective layer severity result BrAtCerCortNeuLosEffLaSevReslt Quantitative result of the severity of cortical neuronal loss in the effective layer of the cerebellum Quantitative result of the severity of cortical neuronal loss in the effective layer of the cerebellum Yes, neuronal loss Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Alphanumeric

Cerebellum; Cortical neuronal loss

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Single Pre-Defined Value Selected

C14986 Brain atrophy striatum head of caudate nucleus severity result BrAtStrCauNucHeadSevReslt Quantitative result of the severity of atrophy located in the head of the caudate nucleus (CN) (at the level where the anterior limb of the internal capsule [ALIC] joins with the basal white matter). Quantitative result of the severity of atrophy located in the head of the caudate nucleus (CN) (at the level where the anterior limb of the internal capsule [ALIC] joins with the basal white matter). Head of the CN Mild 1+;Moderate 2+;Severe3+;Very severe 4+ Mild 1+;Moderate 2+;Severe3+;Very severe 4+ Alphanumeric

Striatum atrophy: At the level where the anterior limb of the internal capsule (ALIC) joins with the basal white matter:atrophy

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Single Pre-Defined Value Selected

C15110 Atherosclerotic luminal stenosis percentage range AtheroLuminStenPercentRange Range for the estimated luminal stenosis percentage if stenotic vascular changes (of the circle of Willis) Range for the estimated luminal stenosis percentage if stenotic vascular changes (of the circle of Willis) Yes, stentoic Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Mild 1+=up to 30% stenosis;Moderate 2+=up to 50% stenosis;Severe 3+=up to 8-% stenosis;Very severe 4+=apparent occlusion Alphanumeric

This question is answered only if "Yes stenotic" is answered for "Are there atherosclerotic, either non-stenotic or stenotic vascular changes (of the circle of Willis)?"

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Single Pre-Defined Value Selected

C17759 Striatum atrophy thalamus atrophy status StrAtrophyThalamusAtrophyStat Status of atrophy in the thalamus Status of atrophy in the thalamu Thalamus atrophy Absent;Present Absent;Present Alphanumeric

Striatum atrophy

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Single Pre-Defined Value Selected

CSV