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ALS Functional Rating Scale - Revised (ALSFRS-R)
Please visit this website for more information about the instrument:
Core: Amyotrophic Lateral Sclerosis (ALS)
Short Description of Instrument
The ALS Functional Rating Scale is a 10-item rating scale that measures the progression of disability in patients with ALS. The ALSFRS assesses patients' levels of self-sufficiency in areas of feeding, grooming, ambulation and communication.
The Revised version was introduced to gather additional information related to sleeping and breathing. It consists of 12 questions with a maximum score of 48 points.
Each item is rated on a 4 (0-4) point scale yielding a maximum of 40 points.
The ALS C.A.R.E. Program. (2018). Retrieved 11 Jul 2018, from
The Amyotrophic Lateral Sclerosis Functional Rating Scale. Assessment of activities of daily living in patients with amyotrophic lateral sclerosis. The ALS CNTF treatment study (ACTS) phase I-II Study Group. Arch Neurol. 1996;53(2):141-147.
Castrillo-Viguera C, Grasso DL, Simpson E, Shefner J, Cudkowicz ME. Clinical significance in the change of decline in ALSFRS-R. Amyotroph Lateral Scler. 2010;11(1-2):178-180.
Cedarbaum JM, Stambler N, Malta E, Fuller C, Hilt D, Thurmond B, Nakanishi A. The ALSFRS-R: a revised ALS functional rating scale that incorporates assessments of respiratory function. BDNF ALS Study Group (Phase III). J Neurol Sci. 1999;169(1-2):13-21.
Cedarbaum JM, Stambler N. Performance of the Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS) in multicenter clinical trials. J Neurol Sci. 1997;152 Suppl 1:S1-S9.
Gordon PH. Amyotrophic Lateral Sclerosis: An update for 2013 Clinical Features, Pathophysiology, Management and Therapeutic Trials. Aging Dis. 2013;4(5):295-310.
Gordon PH, Miller RG, Moore DH. ALSFRS-R. Amyotroph Lateral Scler Other Motor Neuron Disord. 2004;5 Suppl 1:90-93


Document last updated July 2019