Report Viewer

NINDS CDE Notice of Copyright
The International Parkinson and Movement Disorder Society - Non-Motor Rating Scale (MDS-NMS) (GI Domain)
Please visit this website for more information about the instrument: The International Parkinson and Movement Disorder Society - Non-Motor Rating Scale (GI Domain)
Supplemental: Parkinson's Disease (PD)
Short Description of Instrument
The MDS-NMS is a revised version of the Non-Motor Symptoms Scale (NMSS). It is an assessment of non-motor symptoms in Parkinson's disease (PD).
The scale is rater-completed. Frequency and severity of PD and treatment related non-motor symptoms are measured (over the past month) across 13 non-motor domains. This version goes into greater detail than the previous NMSS.
Questions assess change in non-motor symptoms in relation to the timing of anti-parkinsonian medications.
The scale can be used for patients at all stages of PD.
Comments/Special Instructions
Domain 10 (or "J") of the MDS-NMS scale covers the GI tract. There are 4 GI symptoms covered: drooling, swallowing, nausea, and constipation (defined as stooling less than 3 times weekly).
Scoring and Psychometric Properties
Scoring: Each symptom is scored with respect to the severity (0 to 4 point scale) and frequency (0 to 4 point scale). For each question/symptom, frequency x severity is calculated, and the sum of these products is tallied to get the score for the domain. For the GI domain, total scores can range from 0-16.
Psychometric Properties: The GI domain showed a Cronbach's alpha under the criterion 0.7 (gastrointestinal 0.45). Item homogeneity analysis showed that the GI domain did not exceed the accepted standard 0.30 (gastrointestinal IH 0.16).
Strengths: Easy to administer (10-15 minutes), widely used in PD clinical trials, covers 4 of the most common GI symptoms in PD.
Weaknesses: Limited to just 4 GI symptoms, GI domain psychometric properties are modest compared to some of the other domains within the MDS-NMS.
Key Reference:
Martinez-Martin P, Schrag A, Weintraub D, Rizos A, Rodriquez-Blazquez C, Chaudhuri KR. Pilot Study of the International Parkinson and Movement Disorder Society-Sponsored Non-motor Rating Scale (MDS-NMS). Movement Disorders Clinical Practice. 2019 Jan;6(3):227-234.
Chaudhuri KR, Schrag A, Weintraub D, Rizos A, Rodriguez-Blazquez C, Mamikonyan E, Martinez-Martin P. The movement disorder society nonmotor rating scale: Initial validation study. Mov Disord. 2020 Jan;35(1):116-133.
Additional References:
Chaudhuri KR, Martinez-Martin P, Brown RG, Sethi K, Stocchi F, Odin P, Ondo W, Abe K, Macphee G, Macmahon D, Barone P, Rabey M, Forbes A, Breen K, Tluk S, Naidu Y, Olanow W, Williams AJ, Thomas S, Rye D, Tsuboi Y, Hand A, Schapira AH. The metric properties of a novel non-motor symptoms scale for Parkinson's disease: Results from an international pilot study. Mov Disord. 2007 Oct 15;22(13):1901-11.
Chaudhuri KR, Martinez-Martin P, Schapira AH, Stocchi F, Sethi K, Odin P, Brown RG, Koller W, Barone P, MacPhee G, Kelly L, Rabey M, MacMahon D, Thomas S, Ondo W, Rye D, Forbes A, Tluk S, Dhawan V, Bowron A, Williams AJ, Olanow CW. International multicenter pilot study of the first comprehensive self-completed nonmotor symptoms questionnaire for Parkinson's disease: the NMSQuest study. Mov Disord. 2006 Jul;21(7):916-23.
Martinez-Martin P, Rodriguez-Blazquez C, Abe K, Bhattacharyya KB, Bloem BR, Carod-Artal
FJ, Prakash R, Esselink RA, Falup-Pecurariu C, Gallardo M, Mir P, Naidu Y, Nicoletti A, Sethi K, Tsuboi Y, van Hilten JJ, Visser M, Zappia M, Chaudhuri KR. International study on the psychometric attributes of the non-motor symptoms scale in Parkinson disease. Neurology. 2009 Nov 10;73(19):1584-91.
Martinez-Martin P, Rojo-Abuín JM, Weintraub D, Chaudhuri K, Rodriguez-Blázquez C, Rizos A, Schrag A. Factor Analysis and Clustering of the Movement Disorder Society-Non-Motor Rating Scale. Mov Disord. 2020 Jun;35(6):969-975.
Rodriguez-Blazquez C, Forjaz MJ, Frades-Payo B, de Pedro-Cuesta J, Martinez-Martin P; Longitudinal Parkinson's Disease Patient Study, Estudio Longitudinal de Pacients con Enfermedad da Parkinson Group. Independent validation of the scales for outcomes in Parkinson's disease-autonomic (SCOPA-AUT). Eur J Neurol. 2010 Feb;17(2):194-201.
Document Last Updated August 2022