CDE Detailed Report

Disease: Huntington's Disease
Subdomain Name: Other Clinical Data
CRF: Neuropathology Data Form

Displaying 1 - 50 of 175
CDE ID CDE Name Variable Name Definition Short Description Question Text Permissible Values Description Data Type Disease Specific Instructions Disease Specific Reference Population Classification (e.g., Core) Version Number Version Date CRF Name (CRF Module / Guidance) Subdomain Name Domain Name Size Input Restrictions Min Value Max Value Measurement Type External Id Loinc External Id Snomed External Id caDSR External Id CDISC
C08169 Antibody stain method name AntibdyStainMethdName Name of staining method used for antibodies Name of staining method used for antibodies Antibodies Alphanumeric

Answer for each type of microscopic brain abnormality

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C15083 Brain atrophy cerebellum dentate nucleus neuronal loss severity result BrAtCerebDenNucNeurLosSevReslt Quantitative result of the severity of neuronal loss in the dentate nucleus of the cerebellum Quantitative result of the severity of neuronal loss in the dentate nucleus of the cerebellu Yes, neuronal loss Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Alphanumeric

Cerebellum; Dentate nucleus: Neuronal loss

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Single Pre-Defined Value Selected

C14991 Brain atrophy striatum status cribrosus lacunaris status BrAtStrStatusCribLacStat Status of atrophy in the status cribrosus or lacunaris Status of atrophy in the status cribrosus or lacunari Status cribrosus or lucanaris, or both Absent;Present Absent;Present Alphanumeric

Striatum atrophy

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Single Pre-Defined Value Selected

C17753 Macroscopic examination brain text MacroExamBrainTxt Note regarding macroscopic examination of fresh or fixed brain parts Note regarding macroscopical examination of fresh or fixed brain parts Macroscopical examination Note Alphanumeric No references available Adult Supplemental 3.00 2013-08-30 17:06:52.8 Neuropathology Data Form Other Clinical Data Assessments and Examinations 255

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C15051 Brain atrophy cerebral white matter myelin loss indicator BrAtCereWMMyelinLossInd Indicator of myelin loss in the cerebral white matter Indicator of myelin loss in the cerebral white matter Cerebral white matter Myelin loss No myelin loss;Yes myelin loss No myelin loss;Yes myelin loss Alphanumeric

No additional instructions

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Single Pre-Defined Value Selected

C15062 Brain atrophy nucleus coeruleus Lewy body containing neurons and Lewy neurites severity result BrAtNucCoerLeBodLeNeuSevReslt Quantitative result of the severity of lewy-body containing neurons (LBCN) and lewy neurites (LN) in the nucleus coeruleus Quantitative result of the severity of lewy-body containing neurons (LBCN) and lewy neurites (LN) in the nucleus coeruleu Present Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Alphanumeric

Nucleus coeruleus

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Single Pre-Defined Value Selected

C14970 Brain harvesting date and time BrainHarvestingDateTime Date and time, if known the brain was harvested Date and time, if known the brain was harvested Date of Harvesting; Time of Harvesting Date or Date & Time

Record the date/time according to the ISO 8601, the International Standard for the representation of dates and times (http://www.iso.org/iso/home.html). The date/time should be recorded to the level of granularity known (e.g., year, year and month, complete date plus hours and minutes, etc.).

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C15094 Lacunes single or multiple description text LacunesSingMultiDescriptTxt The text description of the lacunes The text description of the lacunes Describe Alphanumeric

Answer for each vascular territory and event category

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C15030 Brain atrophy cortical neuronal nuclear inclusions severity result BrAtCorticalNeurNucIncSevReslt Quantitative result of the severity of cortical neuronal nuclear inclusions Quantitative result of the severity of cortical neuronal nuclear inclusion Present 0;1+/4+;2+/4+;3+/4+;4+/4+ 0=None;1+/4+=Mild;2+/4+=Moderate;3+/4+=Severe;4+/4+=Very severe Alphanumeric

This question is answered for each of the brain anatomic sites.

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Single Pre-Defined Value Selected

C00035 Gender type GenderTyp Self-reported gender of the participant/subject Self-reported gender of the participant/subjec Gender Alphanumeric

Choose one

The NIH Guidelines on Inclusion of Women and Minorities as Subjects in Clinical Research: The Office of Management and Budget Directive No. 15 (http://grants.nih.gov/grants/funding/women_min/guidelines_update.htm) Adult;Pediatric Core 3.00 2013-08-28 16:08:00.453 Neuropathology Data Form Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

2200604
C18993 Macroscopical examination fixed brain other text MacroExamFixedBrainOTH The free-text field related to 'Macroscopical examination fixed brain source' specifying other text. The part(s) of the fixed brain used for macroscopical examination The free-text field related to 'Macroscopical examination fixed brain source' specifying other text. The part(s) of the fixed brain used for macroscopical examination Other, specify Alphanumeric

Indicate the parts selected for evaluation

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C08155 CSF postmortem indicator CSFPstmortemInd Indicator of whether banked postmortem cerebrospinal fluid (CSF) is accessible Indicator of whether banked postmortem cerebrospinal fluid (CSF) is accessible Is banked postmortem CSF available? Yes;No Yes;No Alphanumeric

No additional instructions

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Single Pre-Defined Value Selected

C15073 Brain atrophy cerebellum cortical neuronal loss in associative layer indicator BrAtCerebCortNeurLossAssocInd Indicator of cortical neuronal loss in the associative layer (molecular) of the cerebellum Indicator of cortical neuronal loss in the associative layer (molecular) of the cerebellum Associative layer (molecular) No, neuronal loss;Yes, neuronal loss No, neuronal loss;Yes, neuronal loss Alphanumeric

Cerebellum; Cortical neuronal loss

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C14981 Brain atrophy coronal sections hippocampal formation status BrainAtrophyCorSecHipcamFrStat Status of hippocampal formation atrophy of the coronal sections upon gross examination Status of hippocampal formation atrophy of the coronal sections upon gross examinatio Hippocampal formation atrophy Absent;Present Absent;Present Alphanumeric

Coronal slices: On gross examination of the coronal sections

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Single Pre-Defined Value Selected

C15105 Diagnosis concomitant main indicator DiagnosConcomitantMainInd Indicator of whether the participant/ subject been diagnosed with a concomitant disease Indicator of whether the participant/ subject been diagnosed with a concomitant disease CONCOMITANT MAIN DIAGNOSIS Yes;No;Unknown;Not assessed Yes;No;Unknown;Not assessed Alphanumeric

No additional instructions

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C15041 Brain atrophy neuronal loss severity result BrAtNeurLossSevReslt Quantitative result of the severity of neuronal loss in each location of the caudate nucleus Quantitative result of the severity of neuronal loss in each location of the caudate nucleus Yes, neuronal loss 0;1+/4+;2+/4+;3+/4+;4+/4+;NA 0=None;1+/4+=Mild;2+/4+=Moderate;3+/4+=Severe;4+/4+=Very severe;NA=Not available Alphanumeric

Answer for caudate nucleus, pontes griseum or gray matter caudo-lenticular bridges, putamen, and globus pallidus anatomic sites.

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Single Pre-Defined Value Selected

C08170 Neuritic plaque density category NeuriticPlaqDenstyCat Density of neuritic plaques (plaques with argyrophilic dystrophic neurites with or without dense amyloid cores) Density of neuritic plaques (plaques with argyrophilic dystrophic neurites with or without dense amyloid cores Neuritic plaques (plaques with amyloid core surrounded by a halo with dystrophic neurites) No plaques;Sparse plaques (Up to 2 per 100X field);Moderate plaques (Up to 6 per 100X field);Frequent plaques (>7 per 100X field);Not assessed;Unknown No plaques;Sparse plaques (Up to 2 per 100X field);Moderate plaques (Up to 6 per 100X field);Frequent plaques (>7 per 100X field);Not assessed;Unknown Alphanumeric

Amyloid plaques

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C15084 Brain atrophy Braak and Braak neurofibrillary stage indicator BrAtBraakBraakNeurofibStageInd Indicator of whether neuronal tangles are present Indicator of whether neuronal tangles are present Braak & Braak Neurofibrillary Tangle Stage Absent;Present;Not assessed;Not available Absent;Present;Not assessed;Not available Alphanumeric

No additional instructions

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Single Pre-Defined Value Selected

C14992 Brain atrophy striatum status cribrosus or lacunaris severity result BrAtStrStatusCribLacunSevReslt Quantitative result of the severity of atrophy located in the status cribrosus or lacunaris, or both Quantitative result of the severity of atrophy located in the status cribrosus or lacunaris, or bot Present Mild 1+;Moderate 2+;Severe3+;Very severe 4+ Mild 1+;Moderate 2+;Severe3+;Very severe 4+ Alphanumeric

Striatum atrophy

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Single Pre-Defined Value Selected

C17754 Microscopic examination brain text MicroExamBrainTxt Note regarding microscopic examination of blockage source Note regarding microscopical examination of blockage source Microscopical examination Note Alphanumeric No references available Adult Supplemental 3.00 2013-08-30 17:06:52.8 Neuropathology Data Form Other Clinical Data Assessments and Examinations 255

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C15052 Brain atrophy cerebral white matter myelin loss severity result BrAtCereWMMyelinLosSevReslt Quantitative result of the cerebral white matter myelin loss Quantitative result of the cerebral white matter myelin loss Yes, myelin loss 0;1+/4+;2+/4+;3+/4+;4+/4+ 0=None;1+/4+=Mild;2+/4+=Moderate;3+/4+=Severe;4+/4+=Very severe Alphanumeric

This question is answered if "Yes, myelin loss" is answered for 'Cerebral white matter: myelin loss". This question is answered for each brain anatomic site.

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Single Pre-Defined Value Selected

C15063 Brain atrophy nucleus coeruleus globosum neuronal tangles status BrAtNucCoerGloNeurTanglesStat Status of globosum neuronal tangles (GNT) in the nucleus coeruleus Status of globosum neuronal tangles (GNT) in the nucleus coeruleu Globosum neuronal tangles (GNT) Absent;Present Absent;Present Alphanumeric

Nucleus coeruleus

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Single Pre-Defined Value Selected

C14971 Macroscopical examination fresh brain source MacroExamFreshBrainSource The part(s) of the fresh brain used for macroscopical examination The part(s) of the fresh brain used for macroscopical examination Macroscopical examination Fresh Whole brain;Left half brain;Right half brain;Not available;Other specify Whole brain;Left half brain;Right half brain;Not available;Other specify Alphanumeric

Indicate the parts selected for evaluation

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Single Pre-Defined Value Selected

C15095 Hemorrhages single or multiple event category HemorrhageSingMultiEvntCat Category of the hemorrhages Category of the hemorrhages Yes Single;Multiple Single;Multiple Alphanumeric

No additional instructions

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Single Pre-Defined Value Selected

C15031 Brain atrophy hippocampal formation neuronal loss indicator BrAtHippocampFormNeurLossInd Indicator of neuronal loss in the hippocampal formation Indicator of neuronal loss in the hippocampal formatio Hippocampal formation Neuronal loss No neuronal loss;Yes neuronal loss No neuronal loss;Yes neuronal loss Alphanumeric

No additional instructions

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Single Pre-Defined Value Selected

C02411 Laterality type LatTyp Laterality type relative to the anatomic site of the body examined or affected Laterality type relative to the anatomic site of the body examined or affected Bilateral;Left;Right;Unknown Bilateral;Left;Right;Unknown Alphanumeric No references available Adult;Pediatric Supplemental 3.00 2013-08-28 16:08:00.453 Neuropathology Data Form Other Clinical Data Assessments and Examinations

Single Pre-Defined Value Selected

C18994 Microscopical examination blocks other text MicroExamBlocksOTH The free-text field related to 'Microscopical examination blocks source' specifying other text. The source of blockage based on microscopical examination of brain The free-text field related to 'Microscopical examination blocks source' specifying other text. The source of blockage based on microscopical examination of brain Other, specify Alphanumeric

Indicate the parts selected for evaluation

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C08156 Specimen other postmortem indicator SpecmnOtherPstmortemInd Indicator whether other banked postmortem specimens (e.g., blood, spinal cord, nerve, muscle) exist Indicator whether other banked postmortem specimens (e.g., blood, spinal cord, nerve, muscle) exist Are other banked postmortem specimens available? (e.g. blood, spinal cord, nerve, muscle) Yes;No Yes;No Alphanumeric

If YES is answered then explain what other type(s) of postmortem samples exist

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C15074 Brain atrophy cerebellum cortical neuronal loss in associative layer severity result BrAtCerCortNeurLosAsocSevReslt Quantitative result of the severity of cortical neuronal loss in the associative layer of the cerebellum Quantitative result of the severity of cortical neuronal loss in the associative layer of the cerebellum Yes, neuronal loss Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Alphanumeric

Cerebellum; Cortical neuronal loss

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C14982 Brain atrophy coronal sections hippocampal formation severity result BrAtCorSecHippFormSevReslt Quantitative result of the severity of hippocampal formation atrophy in the coronal sections of the brain Quantitative result of the severity of hippocampal formation atrophy in the coronal sections of the brain Present Mild 1+;Moderate 2+;Severe3+;Very severe 4+ Mild 1+;Moderate 2+;Severe3+;Very severe 4+ Alphanumeric

Coronal slices: On gross examination of the coronal sections

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C15106 Clinicopathology diagnosis final type ClinicopathDiagnosFinalTyp The participant/subject's final clinicopathological diagnosis The participant/subject's final clinicopathological diagnosis Yes Huntington's disease;Encephalopathy of hypoxic-ischemic type, acute;Alzheimer changes;Status cribrosus and lucanaris;There is no diagnostic abnormality recognized;Other, specify Huntington's disease;Encephalopathy of hypoxic-ischemic type, acute;Alzheimer changes;Status cribrosus and lucanaris;There is no diagnostic abnormality recognized;Other, specify Alphanumeric

No additional instructions

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C15042 Brain atrophy fibrillary astrocytosis severity result BrAtFibAstroSevReslt Quantitative result of the severity of fibrillary astrocytosis in each location of the caudate nucleus Quantitative result of the severity of fibrillary astrocytosis in each location of the caudate nucleus Yes, neuronal loss 0;1+/4+;2+/4+;3+/4+;4+/4+;NA 0=None;1+/4+=Mild;2+/4+=Moderate;3+/4+=Severe;4+/4+=Very severe;NA=Not available Alphanumeric

Answer for caudate nucleus, pontes griseum or gray matter caudo-lenticular bridges, putamen, and globus pallidus anatomic sites.

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C08171 Diffuse plaques density category DiffusePlaqDenstyCat Density of diffuse plaques (plaques with non-compact amyloid and no apparent dystrophic neurites) Density of diffuse plaques (plaques with non-compact amyloid and no apparent dystrophic neurites) Immatue and diffuse type plaques (are plaques without the dense core of the neuritic plaques and are either with [immature] or without [diffuse] dystrophic neurites) No plaques;Sparse plaques;Moderate plaques;Frequent plaques;Not assessed;Unknown No plaques;Sparse plaques;Moderate plaques;Frequent plaques;Not assessed;Unknown Alphanumeric

Amyloid plaques

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C15085 Silver staining methods type SilverStainMethdsTyp Silver staining methods used for identifying Alzheimer disease type changes Silver staining methods used for identifying Alzheimer disease type changes Silver methods Bielschowsky;Other, specify;Not assessed;Missing/Unknown Bielschowsky;Other, specify;Not assessed;Missing/Unknown Alphanumeric

Answer for each type of microscopic brain abnormality

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C15021 Brain atrophy substantia nigra appearance grade BrAtSubstantiaNigraAppGrade Grade of pigmentation of the substantia nigra Grade of pigmentation of the substantia nigra Substantia nigra Well pigmented;Darker 1+;Darker 2+;Darker 3+;Very severe 4+ (Darker);Paler 1+;Paler 2+;Paler 3+;Very severe 4+ (Paler) Well pigmented;Darker 1+;Darker 2+;Darker 3+;Very severe 4+ (Darker);Paler 1+;Paler 2+;Paler 3+;Very severe 4+ (Paler) Alphanumeric

Striatum atrophy

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C17755 Striatum atrophy claustrum atrophy status StrAtrophyClaustrumAtrophyStat Status of atrophy in the claustrum Status of atrophy in the claustru Claustrum atrophy Absent;Present Absent;Present Alphanumeric

Striatum atrophy

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C17764 Striatum atrophy red nucleus atrophy severity result StrAtrophyRedNuAtrophySevReslt Quantitative result of the severity of atrophy located in the red nucleus Quantitative result of the severity of atrophy located in the red nucleu Present Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Alphanumeric

Striatum atrophy

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C15053 Brain atrophy substantia nigra pars compacta neuronal loss indicator BrAtSubNigraParsCompNeurLosInd Indicator of neuronal loss in the pars compacta of the substantia nigra Indicator of neuronal loss in the pars compacta of the substantia nigr Pars compacta Neuronal loss No neuronal loss;Yes neuronal loss No neuronal loss;Yes neuronal loss Alphanumeric

Substantia nigra

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C15064 Brain atrophy nucleus coeruleus globosum neuronal tangles (GNT) severity result BrAtNucCoerGloNeurTanSevReslt Quantitative result of the severity of GNT in the nucleus coeruleus Quantitative result of the severity of GNT in the nucleus coeruleu Present Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Mild 1+;Moderate 2+;Severe 3+;Very severe 4+ Alphanumeric

Nucleus coeruleus

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C14972 Macroscopical examination fixed brain source MacroExamFixedBrainSource The part(s) of the fixed brain used for macroscopical examination The part(s) of the fixed brain used for macroscopical examination Macroscopical examination Fixed Whole brain;Left half brain;Right half brain;Not available;Other, specify Whole brain;Left half brain;Right half brain;Not available;Other, specify Alphanumeric

Indicate the parts selected for evaluation

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C15096 Hemorrhages single or multiple vascular territories name HemSingMultiVascTerrName Name of the vascular territories where hemorrhages occur Name of the vascular territories where hemorrhages occur Vascular territories (ACA anterior cerebral artery; MCA middle cerebral artery; PCA posterior cerebral artery) ACA;MCA;PCA;Combined ACA=anterior cerebral artery;MCA=middle cerebral artery;PCA=posterior cerebral artery; Alphanumeric

No additional instructions

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C15032 Brain atrophy hippocampal formation neuronal loss severity result BrAtHippocFormNeurLossSevReslt Quantitative result of the severity of neuronal loss in the hippocampal formation Quantitative result of the severity of neuronal loss in the hippocampal formation Yes, neuronal loss 1+/4+;2+/4+;3+/4+;4+/4+ 1+/4+=Mild;2+/4+=Moderate;3+/4+=Severe;4+/4+=Very severe Alphanumeric

This question is answered if 'Yes, neuronal loss' is answered for 'Hippocampal formation neuronal loss'

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C04802 Death date and time DeathDateTime Date (and time, if known) of participant's/subject's death Date (and time, if known) of participant's/subject's death Date of Death; Time of Death Date or Date & Time

Record the date/time according to the ISO 8601, the International Standard for the representation of dates and times (http://www.iso.org/iso/home.html). The date/time should be recorded to the level of granularity known (e.g., year, year and month, complete date plus hours and minutes, etc.).

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2004152
C18995 Brain atrophy thalamus neuronal loss nuclei other text BrAtThalamusNeurLossNucOTH The free-text field related to 'Brain atrophy thalamus neuronal loss nuclei name' specifying other text. Name of the nuclei in the thalamus involved in the neuronal loss The free-text field related to 'Brain atrophy thalamus neuronal loss nuclei name' specifying other text. Name of the nuclei in the thalamus involved in the neuronal loss Other, specify Alphanumeric

No additional instructions

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C08157 Photograph macroscopic indicator PhotographsMacroscopicInd Indicator of whether macroscopic photographs were taken Indicator of whether macroscopic photographs were taken Are macroscopic photographs available? Yes;No Yes;No Alphanumeric

If YES is answered explain what macroscopic photographs were taken

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Single Pre-Defined Value Selected

C15075 Brain atrophy cerebellum cortical neuronal loss in receptive layer indicator BrAtCerebCortNeurLossRecLayInd Indicator of cortical neuronal loss in the receptive layer (granular) of the cerebellum Indicator of cortical neuronal loss in the receptive layer (granular) of the cerebellum Receptive layer (granular) No, neuronal loss;Yes, neuronal loss No, neuronal loss;Yes, neuronal loss Alphanumeric

Cerebellum; Cortical neuronal loss

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C14983 Brain atrophy coronal sections amygdala status BrAtCorSecAmygdalaStat Status of amygdala atrophy of the coronal sections upon gross examination Status of amygdala atrophy of the coronal sections upon gross examinatio Amygdala atrophy Absent;Present Absent;Present Alphanumeric

Coronal slices: On gross examination of the coronal sections

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C15107 Huntingtons Disease diagnosis grade HDDiagnosGrade The grade of severity of HD or amyloid angiopathy severity The grade of severity of HD or amyloid angiopathy severity Final Clinicopathological Diagnosis Grade 1;Grade 2;Grade 3;Grade 4 Grade 1;Grade 2;Grade 3;Grade 4 Alphanumeric

Only answered if "Huntington disease" or "Cerebral amyloid angiopathy" are answered for Final Clinicopathological diagnoses

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C15043 Brain atrophy thalamus neuronal loss indicator BrAtThalamusNeurLossInd Indicator of neuronal loss in the thalamus Indicator of neuronal loss in the thalamu Thalamus Neuronal loss No neuronal loss;Yes neuronal loss No neuronal loss;Yes neuronal loss Alphanumeric

No additional instructions

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Single Pre-Defined Value Selected

C08173 Ischemic hemorrhagic or vascular pathology indicator IschHemVasclPathInd Indicator of the presence of ischemic, hemorrhagic, or vascular pathology Indicator of the presence of ischemic, hemorrhagic, or vascular pathology Are there ischemic or hemorrhagic changes? Yes;No;Unknown;Not assessed Yes;No;Unknown;Not assessed Alphanumeric

If 'No' is answered for ischemic or hemorrhagic changes, skip to question 43.

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Single Pre-Defined Value Selected

CSV