CDE Detailed Report

Disease: Stroke
Sub-Domain: Classification
CRF: Stroke Types and Subtypes

Displaying 1 - 50 of 88
CDE ID CDE Name Variable Name Definition Short Description Additional Notes (Question Text) Permissible Values Description Data Type Disease Specific Instructions Disease Specific Reference Population Classification (e.g., Core) Version Number Version Date CRF Name (CRF Module / Guideline) Sub Domain Name Domain Name Size Input Restrictions Min Value Max Value Measurement Type External Id Loinc External Id Snomed External Id caDSR External Id CDISC
C58910 Atherosclerosis small-vessel disease cardiac pathology other cause dissection (ASCOD) system - dissection grade ASCODSystemDissectionGrade The grade of dissection, as part of the atherosclerosis small-vessel disease cardiac pathology other cause dissection (ASCOD) system. Patients are evaluated for the predefined phenotype of dissection (D). The grade of dissection, as part of the atherosclerosis small-vessel disease cardiac pathology other cause dissection (ASCOD) system. Patients are evaluated for the predefined phenotype of dissection (D). Evaluate the patients for the predefined phenotype of dissection (D) 0;1;2;3;9 No dissection detected or suspected. Ruling out dissection: negative FAT-saturated MRI of suspected artery or good quality, normal X-ray angiography (too early FAT-saturated MRI performed within 3 days of symptom onset can be falsely negative and then should be repeated). If there is no clinical suspicion of dissection, the patient can be classified D0 provided good-quality extra- or intracranial cerebral artery and cardiac evaluations have been performed;Potentially causal. (1) arterial dissection by direct demonstration (evidence of mural hematoma: hypersignal on FAT-saturated MRI or at autopsy or on TOF-MRA or CT on axial sections showing both enlargement of the arterial wall by the hematoma with narrowing of the lumen or on echography showing an hypoechoic arterial wall with narrowing of the lumen and sudden enlargement of the carotid or vertebral (V2) artery diameter, (2) arterial dissection by indirect demonstration or by less sensitive or less specific diagnostic test (only long arterial stenosis beyond the carotid bifurcation or in V2, V3 or V4 without demonstration of arterial wall hematoma: on X-ray angiography, and/or echography and/or CTA and/or MRA) or unequivocal US with recanalization during follow-up;Causal link is uncertain. (1) arterial dissection by weak evidence (suggestive clinical history, e.g. painful Horner's syndrome or past history of arterial dissection), (2) imaging evidence of fibromuscular dysplasia of a cerebral artery supplying the ischemic field;Causal link is unlikely but the disease is present. (1) kinking or dolichoectasia without complicated aneurysm or plicature, (2) fibromuscular dysplasia on arteries not supplying the ischemic field;Incomplete workup. In patients aged less than 60 years and with no evidence of A1, A2, S1, C1, or O1 category: no FAT-saturated MRI performed on the extra- or intracranial artery supplying the ischemic field or no X-ray angiography performed (all performed within 15 days of symptom onset) Numeric Values

This data element should be collected along with the other elements from the A-S-C-O-D (Phenotypic) Classification.

Amarenco P, Bogousslavsky J, Caplan LR, Donnan GA, Wolf ME, Hennerici MG. The ASCOD phenotyping of ischemic stroke (Updated ASCO Phenotyping). Cerebrovasc Dis. 2013;36(1):1-5. Adult Supplemental 1.00 2020-05-20 09:14:18.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58921 Focal Cerebral Arteriopathy Severity Score (FCASS) - anterior cerebral artery 2 segment score scale FCASSAntCerbrlArt2SegScrScl The scale which represents the severity of focal cerebral arteriopathy in the A2 segment of the anterior cerebral artery (ACA) score, as part of the Focal Cerebral Arteriopathy Severity Score (FCASS). The scale which represents the severity of focal cerebral arteriopathy in the A2 segment of the anterior cerebral artery (ACA) score, as part of the Focal Cerebral Arteriopathy Severity Score (FCASS). Score A2 0;1;3;4 no involvement;irregularity or banding with no stenosis;stenosis;occlusion Numeric Values Fullerton HJ, Stence N, Hills NK, Jiang B, Amlie-Lefond C, Bernard TJ, Friedman NR, Ichord R, Mackay MT, Rafay MF, Chabrier S, Steinlin M, Elkind MSV, deVeber GA, Wintermark M; VIPS Investigators. Focal Cerebral Arteriopathy of Childhood: Novel Severity Score and Natural History. Stroke. 2018;49(11):2590-2596. Pediatric Supplemental 1.00 2020-05-20 11:42:10.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58895 Clinical stroke tissue based ischemic stroke laterality type ClnStrokeTisBaseIschmStkLatTyp Indicate the laterality of the ischemic stroke Indicate the laterality of the ischemic stroke Laterality Right;Left;Bilateral;Midline;Unknown Right;Left;Bilateral;Midline;Unknown Alphanumeric

No instructions available

No references available Adult;Pediatric Supplemental 1.00 2020-05-19 11:44:07.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58911 Atherosclerosis small vessel disease cardiac pathology other cause dissection (ASCOD) system - sub type ASCODSystemSubTyp Stroke Subtype as defined by the A-S-C-O-D pattern (e.g., A1-S3-C1-O3-D0) Stroke Subtype as defined by the A-S-C-O-D pattern (e.g., A1-S3-C1-O3-D0) Identify the Stroke Subtype as defined by the A-S-C-O-D pattern Alphanumeric

This element combines the 5 separate phenotype grades. It should be collected along with the other elements from the A-S-C-O-D (Phenotypic) Classification. The format is A_S_C_O_D_; where blanks contain numbers 0, 1, 2, 3 or 9.

Amarenco P, Bogousslavsky J, Caplan LR, Donnan GA, Wolf ME, Hennerici MG. The ASCOD phenotyping of ischemic stroke (Updated ASCO Phenotyping). Cerebrovasc Dis. 2013;36(1):1-5. Adult Supplemental 1.00 2020-05-20 09:22:47.0 Stroke Types and Subtypes Classification Disease/Injury Related Events 255

Free-Form Entry

C58922 Focal Cerebral Arteriopathy Severity Score (FCASS) - baseline score FCASSBaselineScore Score related to the baseline sum of the five individual arterial segment scores (without weighting), as part of the Focal Cerebral Arteriopathy Severity Score (FCASS). Score related to the baseline sum of the five individual arterial segment scores (without weighting), as part of the Focal Cerebral Arteriopathy Severity Score (FCASS). Baseline score Numeric Values

Sum the five individual scores (without weighting); the maximum baseline score is 20 (maximum individual segment score of 4 multiplied by 5 arterial segments).

Fullerton HJ, Stence N, Hills NK, Jiang B, Amlie-Lefond C, Bernard TJ, Friedman NR, Ichord R, Mackay MT, Rafay MF, Chabrier S, Steinlin M, Elkind MSV, deVeber GA, Wintermark M; VIPS Investigators. Focal Cerebral Arteriopathy of Childhood: Novel Severity Score and Natural History. Stroke. 2018;49(11):2590-2596. Pediatric Supplemental 1.00 2020-05-20 11:44:32.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Free-Form Entry

0 20
C58896 Clinical stroke tissue based Intracerebral hemorrhage laterality type ClinStokeTissBasedICHLatTyp Indicate the laterality of the intracerebral hemorrhage Indicate the laterality of the intracerebral hemorrhage Laterality Right;Left;Bilateral;Midline;Unknown Right;Left;Bilateral;Midline;Unknown Alphanumeric

No instructions available

No references available Adult;Pediatric Supplemental 1.00 2020-05-19 12:17:39.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58912 Embolic stroke of undetermined source (ESUS) - criteria category ESUSCriteriaCat The descriptive identification criteria categories used to identify Embolic Stroke of Undetermined Source (ESUS). The descriptive identification criteria categories used to identify Embolic Stroke of Undetermined Source (ESUS). Identify Embolic Stroke of Undetermined Source Absence of extracranial or intracranial atherosclerosis causing >=50% luminal stenosis in arteries supplying the area of ischemia;Non-lacunar stroke;No major risk cardioembolic source of embolism;No other specific cause of stroke identified (e.g., arteritis, dissection, migraine/vasospasm, and drug abuse) Absence of extracranial or intracranial atherosclerosis causing >=50% luminal stenosis in arteries supplying the area of ischemia;Non-lacunar stroke;No major risk cardioembolic source of embolism;No other specific cause of stroke identified (e.g., arteritis, dissection, migraine/vasospasm, and drug abuse) Alphanumeric

Select all that apply. Requires all items to be checked.

Hart RG, Diener HC, Coutts SB, Easton JD, Granger CB, O'Donnell MJ, Sacco RL, Connolly SJ; Cryptogenic Stroke/ESUS International Working Group. Embolic strokes of undetermined source: the case for a new clinical construct. Lancet Neurol. 2014;13(4):429-438 Adult Supplemental 1.00 2020-05-20 09:26:26.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Multiple Pre-Defined Values Selected

C58923 Focal Cerebral Arteriopathy Severity Score (FCASS) - delta point score code FCASSDeltaPointScoreCode The score code which represents the change in severity of focal cerebral arteriopathy at the time of follow-up score, as part of the Focal Cerebral Arteriopathy Severity Score (FCASS). The score code which represents the change in severity of focal cerebral arteriopathy at the time of follow-up score, as part of the Focal Cerebral Arteriopathy Severity Score (FCASS). Score Delta Point (only for Follow-up score) (+1);(-1) if interval worsening (progression) not otherwise captured by the follow-up FCASS;if interval improvement not otherwise captured by the follow-up FCAS Numeric Values

Only for Follow-up score

Fullerton HJ, Stence N, Hills NK, Jiang B, Amlie-Lefond C, Bernard TJ, Friedman NR, Ichord R, Mackay MT, Rafay MF, Chabrier S, Steinlin M, Elkind MSV, deVeber GA, Wintermark M; VIPS Investigators. Focal Cerebral Arteriopathy of Childhood: Novel Severity Score and Natural History. Stroke. 2018;49(11):2590-2596. Pediatric Supplemental 1.00 2020-05-20 11:49:37.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58898 Causative Classification System (CCS) - large artery atherosclerosis phenotype status CCSLrgArtryAthrsclrsPhntypStat The status of the predefined large artery atherosclerosis phenotype, as part of the Causative Classification System (CCS). The status of the predefined large artery atherosclerosis phenotype, as part of the Causative Classification System (CCS). Evaluate the patient for the predefined phenotype of large artery atherosclerosis. Major;Minor;Absent;Incomplete Evaluation Major;Minor;Absent;Incomplete Evaluation Alphanumeric

Identify the Ischemic Stroke Subtype based on The Causative Classification System's – standard phenotypic subtypes.

Ay H, Furie KL, Singhal A, Smith WS, Sorensen AG, Koroshetz WJ. An evidence-based causative classification system for acute ischemic stroke. Ann Neurol. 2005;58(5):688-697.<br /> Ay H, Benner T, Arsava EM, Furie KL, Singhal AB, Jensen MB, Ayata C, Towfighi A, Smith EE, Chong JY, Koroshetz WJ, Sorensen AG. A computerized algorithm for etiologic classification of ischemic stroke: the Causative Classification of Stroke System. Stroke. 2007;38(11):2979-2984.<br /> Ay H, Arsava EM, Johnston SC, Vangel M, Schwamm LH, Furie KL, Koroshetz WJ, Sorensen AG. Clinical- and imaging-based prediction of stroke risk after transient ischemic attack: the CIP model. Stroke. 2009;40(1):181-186.<br /><br />Arsava EM, Ballabio E, Benner T, Cole JW, Delgado-Martinez MP, Dichgans M, Fazekas F, Furie KL, Illoh K, Jood K, Kittner S, Lindgren AG, Majersik JJ, Macleod MJ, Meurer WJ, Montaner J, Olugbodi AA, Pasdar A, Redfors P, Schmidt R, Sharma P, Singhal AB, Sorensen AG, Sudlow C, Thijs V, Worrall BB, Rosand J, Ay H; International Stroke Genetics Consortium. The Causative Classification of Stroke system: an international reliability and optimization study. Neurology. 2010;75(14):1277-84. Erratum in: Neurology. 2011;76(2):202.<br /> Arsava EM, Helenius J, Avery R, Sorgun MH, Kim GM, Pontes-Neto OM, Park KY, Rosand J, Vangel M, Ay H. Assessment of the Predictive Validity of Etiologic Stroke Classification. JAMA Neurol. 2017;74(4):419-426. Adult Supplemental 1.00 2020-05-19 12:41:08.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58913 Perinatal arterial ischemic stroke type PerinatalArtIschmcStrkTyp Indicates the type of perinatal arterial ischemic stroke (PAIS) suffered by the neonate. Indicates the type of perinatal arterial ischemic stroke (PAIS) suffered by the neonate. Perinatal arterial ischemic stroke (PAIS) Acute perinatal arterial ischemic stroke;Presumed pre- or perinatal stroke Acute perinatal arterial ischemic stroke;Presumed pre- or perinatal stroke Alphanumeric

Choose one per stroke event.

Raju TN, Nelson KB, Ferriero D, Lynch JK, NICHD-NINDS Perinatal Stroke Workshop Participants. Ischemic perinatal stroke: summary of a workshop sponsored by the National Institute of Child Health and Human Development and the National Institute of Neurological Disorders and Stroke. Pediatrics. 2007;120(3):609-616. Kirton A, DeVeber G, Pontigon AM, MacGregor D, Shroff M. Presumed perinatal ischemic stroke: vascular classification predicts outcomes. Ann Neurol.2008;63(4):436-443. Ferriero DM, Fullerton HJ, Bernard TJ, Billinghurst L, Daniels SR, DeBaun MR, deVeber G, Ichord RN, Jordan LC, Massicotte P, Meldau J, Roach ES, Smith ER; American Heart Association Stroke Council and Council on Cardiovascular and Stroke Nursing. Management of Stroke in Neonates and Children: A Scientific Statement From the American Heart Association/American Stroke Association. Stroke. 2019;50(3):e51-e96. Pediatric Supplemental?Highly Recommended 1.00 2020-05-20 10:01:27.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58924 Focal Cerebral Arteriopathy Severity Score (FCASS) - follow up sum score FollowUpSumScore Score related to the follow-up sum of the five individual arterial segment scores (without weighting) and the delta point (if applicable), as part of the Focal Cerebral Arteriopathy Severity Score (FCASS). Score related to the follow-up sum of the five individual arterial segment scores (without weighting) and the delta point (if applicable), as part of the Focal Cerebral Arteriopathy Severity Score (FCASS). Follow-up score Numeric Values

For follow-up imaging, sum the five individual scores (without weighting) and apply the delta point if applicable. The maximum follow-up score is 21 (20 plus the delta point).

Fullerton HJ, Stence N, Hills NK, Jiang B, Amlie-Lefond C, Bernard TJ, Friedman NR, Ichord R, Mackay MT, Rafay MF, Chabrier S, Steinlin M, Elkind MSV, deVeber GA, Wintermark M; VIPS Investigators. Focal Cerebral Arteriopathy of Childhood: Novel Severity Score and Natural History. Stroke. 2018;49(11):2590-2596. Pediatric Supplemental 1.00 2020-05-20 11:54:59.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Free-Form Entry

0 20
C58899 Causative Classification System (CCS) - cardiac embolism phenotype status CCSCardiacEmbolismPhntypStat The status of the predefined cardiac embolism phenotype, as part of the Causative Classification System (CCS). The status of the predefined cardiac embolism phenotype, as part of the Causative Classification System (CCS). Evaluate the patient for the predefined phenotype of cardiac embolism. Major;Minor;Absent;Incomplete Evaluation Major;Minor;Absent;Incomplete Evaluation Alphanumeric

Identify the Ischemic Stroke Subtype based on The Causative Classification System's – standard phenotypic subtypes.

Ay H, Furie KL, Singhal A, Smith WS, Sorensen AG, Koroshetz WJ. An evidence-based causative classification system for acute ischemic stroke. Ann Neurol. 2005;58(5):688-697.<br /> Ay H, Benner T, Arsava EM, Furie KL, Singhal AB, Jensen MB, Ayata C, Towfighi A, Smith EE, Chong JY, Koroshetz WJ, Sorensen AG. A computerized algorithm for etiologic classification of ischemic stroke: the Causative Classification of Stroke System. Stroke. 2007;38(11):2979-2984.<br /> Ay H, Arsava EM, Johnston SC, Vangel M, Schwamm LH, Furie KL, Koroshetz WJ, Sorensen AG. Clinical- and imaging-based prediction of stroke risk after transient ischemic attack: the CIP model. Stroke. 2009;40(1):181-186.<br /><br />Arsava EM, Ballabio E, Benner T, Cole JW, Delgado-Martinez MP, Dichgans M, Fazekas F, Furie KL, Illoh K, Jood K, Kittner S, Lindgren AG, Majersik JJ, Macleod MJ, Meurer WJ, Montaner J, Olugbodi AA, Pasdar A, Redfors P, Schmidt R, Sharma P, Singhal AB, Sorensen AG, Sudlow C, Thijs V, Worrall BB, Rosand J, Ay H; International Stroke Genetics Consortium. The Causative Classification of Stroke system: an international reliability and optimization study. Neurology. 2010;75(14):1277-84. Erratum in: Neurology. 2011;76(2):202.<br /> Arsava EM, Helenius J, Avery R, Sorgun MH, Kim GM, Pontes-Neto OM, Park KY, Rosand J, Vangel M, Ay H. Assessment of the Predictive Validity of Etiologic Stroke Classification. JAMA Neurol. 2017;74(4):419-426. Adult Supplemental 1.00 2020-05-19 12:58:14.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58914 Vascular effects of Infection in Pediatric Stroke (VIPS) - arteriopathy primary diagnosis subtype classification status VIPSArtpthyPrmyDgnSbtypClsStat The status of arteriopathy primary diagnosis, as part of the Vascular effects of Infection in Pediatric Stroke (VIPS) arteriopathy classification system. The status of arteriopathy primary diagnosis, as part of the Vascular effects of Infection in Pediatric Stroke (VIPS) arteriopathy classification system. Indicate the subtype based on the Vascular effects of Infection in Pediatric Stroke (VIPS) arteriopathy classification system. No arteriopathy;Possible arteriopathy;Definite arteriopathy An isolated arterial occlusion in the context of clinical history and/or parenchymal imaging that typifies cardioembolism;An isolated arterial occlusion that could be attributable to either cardioembolism or an in situ arterial abnormality;The imaging appearance of an in situ arterial abnormality (stenosis, irregularity, occlusion, banding, pseudoaneurysm, dissection flap) not attributable to an exogenous thrombus (e.g., cardioembolism) and not considered a normal developmental variant. Alphanumeric

No instructions available

Wintermark M, Hills NK, DeVeber GA, Barkovich AJ, Bernard TJ, Friedman NR, Mackay MT, Kirton A, Zhu G, Leiva-Salinas C, Hou Q, Fullerton HJ; VIPS Investigators. Clinical and Imaging Characteristics of Arteriopathy Subtypes in Children with Arterial Ischemic Stroke: Results of the VIPS Study. AJNR Am J Neuroradiol. 2017;38(11):2172-2179.<br /> Wintermark M, Hills NK, deVeber GA, Barkovich AJ, Elkind MS, Sear K, Zhu G, Leiva-Salinas C, Hou Q, Dowling MM, Bernard TJ, Friedman NR, Ichord RN, Fullerton HJ; VIPS Investigators. Arteriopathy diagnosis in childhood arterial ischemic stroke: results of the vascular effects of infection in pediatric stroke study. Stroke. 2014;45(12):3597-3605. Pediatric Supplemental 1.00 2020-05-20 10:14:49.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58925 Sophia chance findings during routine imaging other text SophiaChncFindDurRoutImgOthTxt The free-text field related to 'Sophia signs and symptoms on presentation type' for chance findings during routine imaging specifying other text. This variable is included along with 8 other classifying variables and clinical context in the Sophia Composite Diagnostic Classification. The free-text field related to 'Sophia signs and symptoms on presentation type' for chance findings during routine imaging specifying other text. This variable is included along with 8 other classifying variables and clinical context. Chance findings during routine imaging, specify Alphanumeric

This element should be collected along with the other elements of the Sophia Classification.

Govaert P, Ramenghi L, Taal R, de Vries L, Deveber G. Diagnosis of perinatal stroke I: definitions, differential diagnosis and registration. Acta Paediatr. 2009;98(10):1556-1567. Pediatric Supplemental 1.00 2020-05-20 12:03:24.0 Stroke Types and Subtypes Classification Disease/Injury Related Events 255

Free-Form Entry

C58901 Causative Classification System (CCS) - small artery occlusion phenotype status CCSSmlArtOcclsnPhntypStat The status of the predefined small artery occlusion phenotype, as part of the Causative Classification System (CCS). The status of the predefined small artery occlusion phenotype, as part of the Causative Classification System (CCS). Evaluate the patient for the predefined phenotype of small artery occlusion. Major;Minor;Absent;Incomplete Evaluation Major;Minor;Absent;Incomplete Evaluation Alphanumeric

Identify the Ischemic Stroke Subtype based on The Causative Classification System's – standard phenotypic subtypes.

Ay H, Furie KL, Singhal A, Smith WS, Sorensen AG, Koroshetz WJ. An evidence-based causative classification system for acute ischemic stroke. Ann Neurol. 2005;58(5):688-697.<br /> Ay H, Benner T, Arsava EM, Furie KL, Singhal AB, Jensen MB, Ayata C, Towfighi A, Smith EE, Chong JY, Koroshetz WJ, Sorensen AG. A computerized algorithm for etiologic classification of ischemic stroke: the Causative Classification of Stroke System. Stroke. 2007;38(11):2979-2984.<br /> Ay H, Arsava EM, Johnston SC, Vangel M, Schwamm LH, Furie KL, Koroshetz WJ, Sorensen AG. Clinical- and imaging-based prediction of stroke risk after transient ischemic attack: the CIP model. Stroke. 2009;40(1):181-186.<br /><br />Arsava EM, Ballabio E, Benner T, Cole JW, Delgado-Martinez MP, Dichgans M, Fazekas F, Furie KL, Illoh K, Jood K, Kittner S, Lindgren AG, Majersik JJ, Macleod MJ, Meurer WJ, Montaner J, Olugbodi AA, Pasdar A, Redfors P, Schmidt R, Sharma P, Singhal AB, Sorensen AG, Sudlow C, Thijs V, Worrall BB, Rosand J, Ay H; International Stroke Genetics Consortium. The Causative Classification of Stroke system: an international reliability and optimization study. Neurology. 2010;75(14):1277-84. Erratum in: Neurology. 2011;76(2):202.<br /> Arsava EM, Helenius J, Avery R, Sorgun MH, Kim GM, Pontes-Neto OM, Park KY, Rosand J, Vangel M, Ay H. Assessment of the Predictive Validity of Etiologic Stroke Classification. JAMA Neurol. 2017;74(4):419-426. Adult Supplemental 1.00 2020-05-19 13:04:42.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58915 Vascular effects of Infection in Pediatric Stroke (VIPS) - arteriopathy secondary diagnosis subtype classification status VIPSArtpthyScdyDgnSbtypClsStat The status of arteriopathy secondary diagnosis, as part of the Vascular effects of Infection in Pediatric Stroke (VIPS) arteriopathy classification system. The status of arteriopathy secondary diagnosis, as part of the Vascular effects of Infection in Pediatric Stroke (VIPS) arteriopathy classification system. If definite arteriopathy, indicate secondary diagnosis Focal cerebral arteriopathy (FCA);Intracranial arterial dissection (This subtype overlaps with FCA-d (above) when dissection occurs in the large intracranial arteries of the anterior circulation.);Extracranial arterial dissection;Bilateral cerebral arteriopathy of childhood (primary moyamoya disease and secondary moyamoya syndromes);Diffuse/multifocal vasculitis;Genetic or syndromic arteriopathy;Other Focal cerebral arteriopathy (FCA);Intracranial arterial dissection (This subtype overlaps with FCA-d (above) when dissection occurs in the large intracranial arteries of the anterior circulation.);Extracranial arterial dissection;Bilateral cerebral arteriopathy of childhood (primary moyamoya disease and secondary moyamoya syndromes);Diffuse/multifocal vasculitis;Genetic or syndromic arteriopathy;Other Alphanumeric

No instructions available

Wintermark M, Hills NK, DeVeber GA, Barkovich AJ, Bernard TJ, Friedman NR, Mackay MT, Kirton A, Zhu G, Leiva-Salinas C, Hou Q, Fullerton HJ; VIPS Investigators. Clinical and Imaging Characteristics of Arteriopathy Subtypes in Children with Arterial Ischemic Stroke: Results of the VIPS Study. AJNR Am J Neuroradiol. 2017;38(11):2172-2179.<br /> Wintermark M, Hills NK, deVeber GA, Barkovich AJ, Elkind MS, Sear K, Zhu G, Leiva-Salinas C, Hou Q, Dowling MM, Bernard TJ, Friedman NR, Ichord RN, Fullerton HJ; VIPS Investigators. Arteriopathy diagnosis in childhood arterial ischemic stroke: results of the vascular effects of infection in pediatric stroke study. Stroke. 2014;45(12):3597-3605. Pediatric Supplemental 1.00 2020-05-20 10:40:29.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58902 Causative Classification System (CCS) - other uncommon cause phenotype status CCSOthrUncmnCausePhntypStat The status of the predefined other uncommon causes phenotype, as part of the Causative Classification System (CCS). The status of the predefined other uncommon causes phenotype, as part of the Causative Classification System (CCS). Evaluate the patient for the predefined phenotype of other uncommon causes. Major;Absent Major;Absent Alphanumeric

Identify the Ischemic Stroke Subtype based on The Causative Classification System's – standard phenotypic subtypes.

Ay H, Furie KL, Singhal A, Smith WS, Sorensen AG, Koroshetz WJ. An evidence-based causative classification system for acute ischemic stroke. Ann Neurol. 2005;58(5):688-697.<br /> Ay H, Benner T, Arsava EM, Furie KL, Singhal AB, Jensen MB, Ayata C, Towfighi A, Smith EE, Chong JY, Koroshetz WJ, Sorensen AG. A computerized algorithm for etiologic classification of ischemic stroke: the Causative Classification of Stroke System. Stroke. 2007;38(11):2979-2984.<br /> Ay H, Arsava EM, Johnston SC, Vangel M, Schwamm LH, Furie KL, Koroshetz WJ, Sorensen AG. Clinical- and imaging-based prediction of stroke risk after transient ischemic attack: the CIP model. Stroke. 2009;40(1):181-186.<br /><br />Arsava EM, Ballabio E, Benner T, Cole JW, Delgado-Martinez MP, Dichgans M, Fazekas F, Furie KL, Illoh K, Jood K, Kittner S, Lindgren AG, Majersik JJ, Macleod MJ, Meurer WJ, Montaner J, Olugbodi AA, Pasdar A, Redfors P, Schmidt R, Sharma P, Singhal AB, Sorensen AG, Sudlow C, Thijs V, Worrall BB, Rosand J, Ay H; International Stroke Genetics Consortium. The Causative Classification of Stroke system: an international reliability and optimization study. Neurology. 2010;75(14):1277-84. Erratum in: Neurology. 2011;76(2):202.<br /> Arsava EM, Helenius J, Avery R, Sorgun MH, Kim GM, Pontes-Neto OM, Park KY, Rosand J, Vangel M, Ay H. Assessment of the Predictive Validity of Etiologic Stroke Classification. JAMA Neurol. 2017;74(4):419-426. Adult Supplemental 1.00 2020-05-19 13:34:35.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58916 Vascular effects of Infection in Pediatric Stroke (VIPS) - focal cerebral arteriopathy type VIPSFCATyp Type of focal cerebral arteriopathy (FCA), as part of the Vascular effects of Infection in Pediatric Stroke (VIPS) arteriopathy classification system. Type of focal cerebral arteriopathy (FCA), as part of the Vascular effects of Infection in Pediatric Stroke (VIPS) arteriopathy classification system. Focal cerebral arteriopathy (FCA) Focal cerebral arteriopathy - dissection type (FCA-d);Focal cerebral arteriopathy - inflammatory type (FCA-i) (includes transient cerebral arteriopathy (TCA)) Focal cerebral arteriopathy - dissection type (FCA-d);Focal cerebral arteriopathy - inflammatory type (FCA-i) (includes transient cerebral arteriopathy (TCA)) Alphanumeric

No instructions available

Wintermark M, Hills NK, DeVeber GA, Barkovich AJ, Bernard TJ, Friedman NR, Mackay MT, Kirton A, Zhu G, Leiva-Salinas C, Hou Q, Fullerton HJ; VIPS Investigators. Clinical and Imaging Characteristics of Arteriopathy Subtypes in Children with Arterial Ischemic Stroke: Results of the VIPS Study. AJNR Am J Neuroradiol. 2017;38(11):2172-2179.<br /> Wintermark M, Hills NK, deVeber GA, Barkovich AJ, Elkind MS, Sear K, Zhu G, Leiva-Salinas C, Hou Q, Dowling MM, Bernard TJ, Friedman NR, Ichord RN, Fullerton HJ; VIPS Investigators. Arteriopathy diagnosis in childhood arterial ischemic stroke: results of the vascular effects of infection in pediatric stroke study. Stroke. 2014;45(12):3597-3605. Pediatric Supplemental 1.00 2020-05-20 11:00:31.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58904 Atherosclerosis small-vessel disease cardiac pathology other cause dissection (ASCOD) system - atherothrombosis grade ASCODSystemAtherothrGrade The grade of atherothrombosis, as part of the atherosclerosis small-vessel disease cardiac pathology other cause dissection (ASCOD) system. Patients are evaluated for the predefined phenotype of atherosclerosis (A). The grade of atherothrombosis, as part of the atherosclerosis small-vessel disease cardiac pathology other cause dissection (ASCOD) system. Patients are evaluated for the predefined phenotype of atherosclerosis (A). Evaluate the patients for the predefined phenotype of atherosclerosis (A). 0;1;2;3;9 Atherosclerosis not detected. Ruling out atherosclerosis: (1) extracranial arterial stenosis: one or several of the following diagnostic tests are performed and are negative: US-Duplex,CTA, MRA, XRA, or autopsy, (2) intracranial arterial stenosis: one or several of the following diagnostic tests are performed and are negative: US-TCD,MRA, CTA, XRA, or autopsy, (3) aortic arch atheroma: TEE with specific assessment of the aortic arch (when the probe is pulled back at the end of the cardiac examination, turn the probe counter clockwise and take time to watch the aortic arch) or specific aortic arch assessment with CTA;Potentially causal. Atherothrombotic stroke defined as: (1) ipsilateral atherosclerotic stenosis between 50 and 99% in an intra- or extracranial artery supplying the ischemic field, or (2) ipsilateral atherosclerotic stenosis;Causal link is uncertain. (1) ipsilateral atherosclerotic stenosis 30–50% in an intra- or extracranial artery supplying the ischemic field, or (2) aortic plaque =4 mm without mobile lesion;Causal link is unlikely, but the disease is present. (1) plaque (stenosis <30%) in an intra- or extracranial artery, ipsilateral to the infarct area, (2) aortic plaque <4 mm without mobile thrombus, (3) stenosis (any degree) or occlusion in a cerebral artery not supplying the infarct area (e.g. contralateral side or opposite circulation), (4) history of myocardial infarction, coronary revascularization or peripheral arterial disease, (5) ipsi- or bilateral atherosclerotic stenosis 50–99% with bihemispheric MR-DWI lesion;Incomplete workup. US-Duplex, US-TCD or CTA, or MRA, or XRA or autopsy not performed. [A minimum workup is extra- and intracranial assessment of cerebral arteries – maximum workup also includes transesophageal assessment of the aortic arch (or a default CTA of the aortic arch)] Numeric Values

This data element should be collected along with the other elements from the A-S-C-O-D (Phenotypic) Classification.

Amarenco P, Bogousslavsky J, Caplan LR, Donnan GA, Wolf ME, Hennerici MG. The ASCOD phenotyping of ischemic stroke (Updated ASCO Phenotyping). Cerebrovasc Dis. 2013;36(1):1-5. Adult Supplemental 1.00 2020-05-19 13:41:48.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58917 Focal Cerebral Arteriopathy Severity Score (FCASS) - supraclinoid internal carotid artery score scale FCASSSupraclinoidICAScoreScl The scale which represents the severity of focal cerebral arteriopathy in the supraclinoid internal carotid artery (ICA) score, as part of the Focal Cerebral Arteriopathy Severity Score (FCASS). The scale which represents the severity of focal cerebral arteriopathy in the supraclinoid internal carotid artery (ICA) score, as part of the Focal Cerebral Arteriopathy Severity Score (FCASS). Score supraclinoid ICA 1;2;3;4;0 irregularity or banding with no stenosis;stenosis, <50% reduction in diameter;stenosis, >50% reduction in diameter;occlusion;no involvement Numeric Values Fullerton HJ, Stence N, Hills NK, Jiang B, Amlie-Lefond C, Bernard TJ, Friedman NR, Ichord R, Mackay MT, Rafay MF, Chabrier S, Steinlin M, Elkind MSV, deVeber GA, Wintermark M; VIPS Investigators. Focal Cerebral Arteriopathy of Childhood: Novel Severity Score and Natural History. Stroke. 2018;49(11):2590-2596. Pediatric Supplemental 1.00 2020-05-20 11:11:28.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58676 Birth sex assigned type BirthSexAssignTyp Self-reported phenotypic sex of participant/subject, assigned at birth. Self-reported phenotypic sex of participant/subject, assigned at birth. Sex assigned at birth Male;Female;Intersex;Unknown;Other, specify Male;Female;Intersex;Unknown;Other, specify Alphanumeric

No instructions available

No references available Adult;Pediatric Core 1.00 2020-01-07 14:00:16.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58907 Atherosclerosis small-vessel disease cardiac pathology other cause dissection (ASCOD) system - small vessel grade ASCODSystemSmallVesselGrade The grade of small vessel disease, as part of the atherosclerosis small-vessel disease cardiac pathology other cause dissection (ASCOD) system. Patients are evaluated for the predefined phenotype of small-vessel disease (S). The grade of small vessel disease, as part of the atherosclerosis small-vessel disease cardiac pathology other cause dissection (ASCOD) system. Patients are evaluated for the predefined phenotype of small-vessel disease (S). Evaluate the patients for the predefined phenotype of small vessel disease (S). 0;1;2;3;9 Small-vessel disease not detected. Ruling out small-vessel disease stroke: negative MRI (T2, FLAIR, GRE, DWI) and no appropriate clinical syndrome suggestive of a deep branch artery stroke;Potentially causal. Combination of: (1) lacunar infarction: small deep infarct <15 mm (in perforator branch territory) on MRI-DWI (or a default CT) in an area corresponding to the symptoms and at least one of the three following criteria: (2) one or several small deep older infarct(s) of lacunar type in other territories, and/or (3) severe (confluent – Fazekas III) leukoaraiosis, or microbleeds, or severe dilatation of perivascular spaces ('État criblÉ'), (4) repeated, recent (<1 month), TIAs attributable to the same territory as the index infarct;Causal link is uncertain. (1) only one, recent, lacunar infarction and no other abnormality on MRI (or CT) or (2) clinical syndrome suggestive of a deep branch artery stroke, without ischemic lesion in the appropriate area seen on MRI or CT (main clinical syndrome suggesting a deep branch artery – lacunar – stroke: pure hemiparesis, pure hemisensory loss, ataxic hemiparesis, dysarthria-clumsy hand syndrome, unilateral sensorimotor deficit, others: hemichorea, hemiballism, pure dysarthria, etc.);Causal link is unlikely, but the disease is present. Severe (confluent – Fazekas III) leukoaraiosis visible on MRI and/or CT scan, and/or microbleeds visible on T2*-weighted MRI, and/or severe dilatation of perivascular spaces (visible on T2-weighted MRI), and/or one or several old, small deep infarcts of lacunar type;Incomplete workup. MRI (or CT) not performed Numeric Values

This data element should be collected along with the other elements from the A-S-C-O-D (Phenotypic) Classification.

Amarenco P, Bogousslavsky J, Caplan LR, Donnan GA, Wolf ME, Hennerici MG. The ASCOD phenotyping of ischemic stroke (Updated ASCO Phenotyping). Cerebrovasc Dis. 2013;36(1):1-5. Adult Supplemental 1.00 2020-05-20 07:50:40.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58918 Focal Cerebral Arteriopathy Severity Score (FCASS) - middle cerebral artery 1 segment score scale FCASSMidCerbrlArt1SegScrScl The scale which represents the severity of focal cerebral arteriopathy in the M1 segment of the middle cerebral artery (MCA) score, as part of the Focal Cerebral Arteriopathy Severity Score (FCASS). The scale which represents the severity of focal cerebral arteriopathy in the M1 segment of the middle cerebral artery (MCA) score, as part of the Focal Cerebral Arteriopathy Severity Score (FCASS). Score M1 1;2;3;4;0 irregularity or banding with no stenosis;stenosis, <50% reduction in diameter;stenosis, >50% reduction in diameter;occlusion;no involvement Numeric Values Fullerton HJ, Stence N, Hills NK, Jiang B, Amlie-Lefond C, Bernard TJ, Friedman NR, Ichord R, Mackay MT, Rafay MF, Chabrier S, Steinlin M, Elkind MSV, deVeber GA, Wintermark M; VIPS Investigators. Focal Cerebral Arteriopathy of Childhood: Novel Severity Score and Natural History. Stroke. 2018;49(11):2590-2596. Pediatric Supplemental 1.00 2020-05-20 11:28:32.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58780 Birth sex assigned type other text BirthSexAssignTypOTH The free-text field related to 'Birth sex assigned type', specifying other text. The free-text field related to 'Birth sex assigned type', specifying other text. Other, specify Alphanumeric

No instructions available

No references available Adult;Pediatric Supplemental 1.00 2020-05-12 10:47:54.0 Stroke Types and Subtypes Classification Disease/Injury Related Events 4000

Free-Form Entry

C58908 Atherosclerosis small-vessel disease cardiac pathology other cause dissection (ASCOD) system - cardioembolic grade ASCODSystemCardioembGrade The grade of cardiac pathology, as part of the atherosclerosis small-vessel disease cardiac pathology other cause dissection (ASCOD) system. Patients are evaluated for the predefined phenotype of cardiac pathology (C). The grade of cardiac pathology, as part of the atherosclerosis small-vessel disease cardiac pathology other cause dissection (ASCOD) system. Patients are evaluated for the predefined phenotype of cardiac pathology (C). Evaluate the patients for the predefined phenotype of cardiac pathology (C). 0;1;2;3;9 Cardiac pathology not detected or not suspected. Ruling out a cardiac source of embolism: minimum is negative ECG and examination by a cardiologist, maximum is negative ECG/telemetry/24-hour Holter ECG/long-term ECG recording (implantable device, transtelephonic ECG, loop recorder) and negative TEE for atrium, valves and septal abnormalities, negative TTE for PFO and assessment of left ventricle, negative cardiac CT/MRI, negative abdominal CT/MRI (search for old or simultaneous subdiaphragmatic visceral infarction);Potentially causal. Cardiogenic stroke defined as acute, or recent and older bihemispheric or supra- and infratentorial territorial or cortical ischemic lesions and signs of systemic embolism with detection of at least one of the following potential causes: (1) mitral stenosis (surface <1.5 cm 2 ), (2) mechanical valve, (3) myocardial infarction within 4 weeks preceding the cerebral infarction, (4) mural thrombus in the left cavities, (5) aneurysm of the left ventricle, (6) history or presence of documented atrial fibrillation – whether paroxysmal (>60 s), persistent or permanent – or flutter, with or without left atrial thrombus or spontaneous echo, (7)atrial disease (tachycardia-bradycardia syndrome), (8) dilated or hypertrophic cardiomyopathies, (9) left ventricle ejection fraction <35%, (10) endocarditis, (11) intracardiac mass, (12) PFO and thrombus in situ, (13) PFO and concomitant pulmonary embolism or proximal DVT preceding the index cerebral infarction, (14) aforementioned cardiac pathologies (C1) with single or without obvious cerebral ischemic lesion;Causal link is uncertain. Regardless of stroke pattern: (1) PFO + atrial septal aneurysm, (2) PFO and pulmonary embolism or proximal DTV concomitant but NOT preceding the index cerebral infarction, (3) intracardiac spontaneous echo-contrast, (4) apical akinesia of the left ventricle and decreased ejection fraction (but >35%), (5) history of myocardial infarction or palpitation and multiple brain infarction, repeated either bilateral or in two different arterial territories (e.g. both anterior and posterior circulation), (6) no direct cardiac source identified, but multiple brain infarction, repeated either bilateral or in two different arterial territories (e.g. both anterior and posterior circulation) and/or evidence of systemic emboli: renal or splenic or mesenteric infarction (on CT, MRI or autopsy) or embolism in peripheral artery supplying arm or leg;Causal link is unlikely, but the disease is present. One of the following abnormalities present in isolation: PFO, ASA, strands, mitral annulus calcification, calcification aortic valve, nonapical akinesia of the left ventricle, transient atrial fibrillation;Incomplete workup. Minimum is ECG and examination by a trained cardiologist in the absence of cardiac imaging. Numeric Values

This data element should be collected along with the other elements from the A-S-C-O-D (Phenotypic) Classification.

Amarenco P, Bogousslavsky J, Caplan LR, Donnan GA, Wolf ME, Hennerici MG. The ASCOD phenotyping of ischemic stroke (Updated ASCO Phenotyping). Cerebrovasc Dis. 2013;36(1):1-5. Adult Supplemental 1.00 2020-05-20 08:40:20.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58919 Focal Cerebral Arteriopathy Severity Score (FCASS) - anterior cerebral artery 1 segment score scale FCASSAntCerbrlArt1SegScrScl The scale which represents the severity of focal cerebral arteriopathy in the A1 segment of the anterior cerebral artery (ACA) score, as part of the Focal Cerebral Arteriopathy Severity Score (FCASS). The scale which represents the severity of focal cerebral arteriopathy in the A1 segment of the anterior cerebral artery (ACA) score, as part of the Focal Cerebral Arteriopathy Severity Score (FCASS). Score A1 1;2;3;4;0 irregularity or banding with no stenosis;stenosis, <50% reduction in diameter;stenosis, >50% reduction in diameter;occlusion;no involvement Numeric Values Fullerton HJ, Stence N, Hills NK, Jiang B, Amlie-Lefond C, Bernard TJ, Friedman NR, Ichord R, Mackay MT, Rafay MF, Chabrier S, Steinlin M, Elkind MSV, deVeber GA, Wintermark M; VIPS Investigators. Focal Cerebral Arteriopathy of Childhood: Novel Severity Score and Natural History. Stroke. 2018;49(11):2590-2596. Pediatric Supplemental 1.00 2020-05-20 11:32:41.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58893 Clinical stroke time based ischemic stroke laterality type ClnStrokeTimBaseIschmSrkLatTyp Indicate the laterality of the ischemic stroke Indicate the laterality of the ischemic stroke Laterality Right;Left;Bilateral;Midline;Unknown Right;Left;Bilateral;Midline;Unknown Alphanumeric

No instructions available

No references available Adult;Pediatric Supplemental 1.00 2020-05-19 09:56:46.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58909 Atherosclerosis small-vessel disease cardiac pathology other cause dissection (ASCOD) system - other grade ASCODSystemOtherGrade The grade of other cause, as part of the atherosclerosis small-vessel disease cardiac pathology other cause dissection (ASCOD) system. Patients are evaluated for the predefined phenotype of other cause (O). The grade of other cause, as part of the atherosclerosis small-vessel disease cardiac pathology other cause dissection (ASCOD) system. Patients are evaluated for the predefined phenotype of other cause (O). Evaluate the patients for the predefined phenotype of other cause (O). 0;1;2;3;9 No other cause detected. Ruling out other causes: negative: cerebrospinal fluid, complete hemostasis, cerebral arterial imaging, family history of inherited disease, inflammatory markers (erythrocyte sedimentation rate, C-reactive protein), hematologic tests (platelet, leucocytes, and eosinophilic counts, hematocrit), specific tests according to the suspected disease (e.g. genetic test, retinal angiography for Susac syndrome);Potentially causal. (1) dolichoectasia with complicated aneurysm, (2) polycythemia vera or thrombocytemia >800,000/mm3, (3) systemic lupus, (4) disseminated intravascular coagulation, (5) antiphospholipid antibody syndrome (including >100 GPL units or lupus anticoagulant), (6) Fabry's disease, (7) coexisting meningitis, (8) sickle cell disease, (9) ruptured intracranial aneurysm with or without vasospasm of the artery supplying the infarcted area, (10) severe hyperhomocysteinemia, (11) Horton's disease, (12) other cerebral inflammatory or infectious angiitis, (13) moyamoya disease, etc.;Causal link is uncertain. (1) saccular aneurysm (with a suspicion of embolism from it), (2) coincidental migraine attack with neurological deficit lasting >60 min in patients with history of migraine aura;Causal link is unlikely but the disease is present. (1) arteriovenous malformation, (2) thrombocythosis <800,000/mm3, (3) antiphospholipid antibody <100 GPL units, (4) homocysteinemia <40 ?mol/l, (5) malignoma with associated hypercoagulation (high D-dimer levels), deep vein thrombosis or pulmonary embolism and/or recent chemotherapy;Incomplete workup. Unable to reasonably exclude other causes based on best available diagnostic tests and stroke-specific history Numeric Values

This data element should be collected along with the other elements from the A-S-C-O-D (Phenotypic) Classification.

Amarenco P, Bogousslavsky J, Caplan LR, Donnan GA, Wolf ME, Hennerici MG. The ASCOD phenotyping of ischemic stroke (Updated ASCO Phenotyping). Cerebrovasc Dis. 2013;36(1):1-5. Adult Supplemental 1.00 2020-05-20 08:55:53.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58920 Focal Cerebral Arteriopathy Severity Score (FCASS) - middle cerebral artery 2 segment score scale FCASSMidCerbrlArt2SegScrScl The scale which represents the severity of focal cerebral arteriopathy in the M2 segment of the middle cerebral artery (MCA) score, as part of the Focal Cerebral Arteriopathy Severity Score (FCASS). The scale which represents the severity of focal cerebral arteriopathy in the M2 segment of the middle cerebral artery (MCA) score, as part of the Focal Cerebral Arteriopathy Severity Score (FCASS). Score M2 0;1;3;4 no involvement;irregularity or banding with no stenosis;stenosis;occlusion Numeric Values Fullerton HJ, Stence N, Hills NK, Jiang B, Amlie-Lefond C, Bernard TJ, Friedman NR, Ichord R, Mackay MT, Rafay MF, Chabrier S, Steinlin M, Elkind MSV, deVeber GA, Wintermark M; VIPS Investigators. Focal Cerebral Arteriopathy of Childhood: Novel Severity Score and Natural History. Stroke. 2018;49(11):2590-2596. Pediatric Supplemental 1.00 2020-05-20 11:35:16.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C58894 Clinical stroke time based Intracerebral hemorrhage laterality type ClinStrokeTimeBasedICHLatTyp Indicate the laterality of the intracerebral hemorrhage Indicate the laterality of the intracerebral hemorrhage Laterality Right;Left;Bilateral;Midline;Unknown Right;Left;Bilateral;Midline;Unknown Alphanumeric

No instructions available

No references available Adult;Pediatric Supplemental 1.00 2020-05-19 11:38:36.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C13835 Graeb intraventricular hemorrhage (IVH) scale - total score GraebIVHScaleTotaScore Indicates Graeb IVH Scale - total Score Indicates Graeb IVH Scale - total Score Total score Numeric Values

To calculate the total, sum the scores for the ventricles. Maximum score is 12.

Graeb DA, Robertson WD, Lapointe JS, Nugent RA, Harrison PB. Computed tomographic diagnosis of intraventricular hemorrhage. Etiology and prognosis. Radiology. 1982;143(1):91-96. Adult;Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Free-Form Entry

0 12
C14258 Perinatal stroke type PerinatalStrokeTyp Indicates the type of clinical stroke suffered by the neonate. Indicates the type of clinical stroke suffered by the neonate. Indicate the type of clinical stroke suffered by the neonate. Perinatal arterial ischemic stroke (PAIS);Perinatal intracerebral hemorrhage (ICH);Perinatal subarachnoid hemorrhage (SAH);Perinatal intraventricular hemorrhage (IVH);Perinatal cerebral venous thrombosis (CVT);Periventricular venous infarction (PVI) Perinatal arterial ischemic stroke (PAIS);Perinatal intracerebral hemorrhage (ICH);Perinatal subarachnoid hemorrhage (SAH);Perinatal intraventricular hemorrhage (IVH);Perinatal cerebral venous thrombosis (CVT);Periventricular venous infarction (PVI) Alphanumeric

Choose one per stroke event.

The "NINDS Stroke Common Data Element (CDE) Project, Stroke Types and Subtypes Subgroup: Recommendations" has detailed definitions for each stroke type. Pediatric Supplemental?Highly Recommended 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C14232 Atherosclerosis small vessel disease cardiac source other cause (ASCO) system - cardioembolic grade ASCOSystemCardioembGrade The grade of cardioembolism, as part of the atherosclerosis small-vessel disease cardiac source other cause (ASCO) system. Patients are evaluated for the predefined phenotype of cardiac source (C). The grade of cardioembolism, as part of the atherosclerosis small-vessel disease cardiac source other cause (ASCO) system. Patients are evaluated for the predefined phenotype of cardiac source (C). Evaluate the patients for the predefined phenotype of cardiac source (C). 0;1;2;3;9 No disease is present;Definitely a potential cause of the index stroke: (a) Mitral stenosis, (b) Prosthetic heart valve, (c) Myocardial infarction within the past 4 weeks, (d) Mural thrombus in left cavities, (e) Left ventricular aneurysm, (f) Any documented history or permanent or transient atrial fibrillation or flutter with or without spontaneous echo contrast or left atrial thrombus, (g) Sick sinus syndrome, (h) Dilated cardiomyopathy, (i) Ejection fraction <35%, (j) Endocarditis, (k) Intracardiac mass, (l) PFO plus in situ thrombosis, (m) PFO plus concomitant PE or DVT preceding the brain infarction.;Causality uncertain: (a) PFO and ASA, (b) PFO and concomitant DVT or PE (but not preceding the index stroke), (c) Spontaneous echo contrast, (d) Apical akinesia of the left ventricle and impaired ejection fraction (but >35%), (e) Only suggested by history of myocardial infarction or palpitation and multiple repeated brain infarcts on both sides or in both the anterior and posterior circulation, (f) Only suggested by abdominal CT/MRI or autopsy demonstration of the presence of systemic infarction (e.g. kidney, splenic, mesenteric) or lower limb embolism (in addition to the index stroke).;Unlikely a direct cause of index stroke: One of the following abnormalities: PFO, ASA, valvular strands, mitral annulus calcification, calcified aortic valve, nonapical akinesia of the left ventricle.;Cannot be graded because no tests were performed Numeric values

This data element should be collected along with the other elements from the A-S-C-O (Phenotypic) Classification.

Amarenco P, Bogousslavsky J, Caplan LR, Donnan GA, Hennerici MG. New approach to stroke subtyping: the A-S-C-O (phenotypic) classification of stroke. Cerebrovasc Dis. 2009;27(5):502-508 Adult Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C14271 Sophia imaging stroke composite diagnosis method type SophiaImgStrokCompDiaMethTyp Imaging method at detection. This variable is included along with 8 other classifying variables and clinical context in the Sophia Composite Diagnostic Classification. Imaging method at detection. This variable is included along with 8 other classifying variables and clinical context in the Sophia Composite Diagnostic Classification. Identify the imaging method at detection. Ultrasound;MRI/MRA/MRV;CT;Other, specify Ultrasound;MRI/magnetic resonance angiography/magnetic resonance venography;CT;Other, specify Alphanumeric

Choose all that apply. This element should be collected along with the other elements of the Sophia Classification.

Govaert P, Ramenghi L, Taal R, de Vries L, Deveber G. Diagnosis of perinatal stroke I: definitions, differential diagnosis and registration. Acta Paediatr. 2009;98(10):1556-1567. Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Multiple Pre-Defined Values Selected

C14248 Ogilvy subarachnoid hemorrhage grade OgilvySubarachnoidHemGrade Ogilvy comprehensive grading system for classifying severity of SAH. In the system, 1 point is assigned for Hunt and Hess Grade 4 or 5, Fisher Scale score of 3 or 4, aneurysm size greater than 10 mm, patient age older than 50 years, and if the lesion is a giant (>= 25 mm) posterior circulation lesion. By adding the total points, the 5-point grading system is obtained. Ogilvy comprehensive grading system for classifying severity of SAH. In the system, 1 point is assigned for Hunt and Hess Grade 4 or 5, Fisher Scale score of 3 or 4, aneurysm size greater than 10 mm, patient age older than 50 years, and if the lesion is Ogilvy subarachnoid hemorrhage (SAH) grading system 1;2;3;4;5 Dead;Poor;Fair;Good;Excellent Numeric values

Add the total points as described in the definition to calculate the Ogilvy grade.

Ogilvy CS, Carter BS. A proposed comprehensive grading system to predict outcome for surgical management of intracranial aneurysms. Neurosurgery 1998;42(5):959-968. Adult Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C14219 Clinical stroke time-based definition indicator ClinStrokeTimeBasedDefinInd Indicates whether the patient suffered a clinical stroke according to the following, "time-based" definition: Stroke is a sudden focal neurological deficit of presumed vascular origin lasting >= 24 hours (or fatal within 24 hours). Indicates whether the patient suffered a clinical stroke according to the following, "time-based" definition: Stroke is a sudden focal neurological deficit of presumed vascular origin lasting >= 24 hours (or fatal within 24 hours). Has the patient suffered a stroke according to the "time-based" definition? Yes;No;Unknown Yes;No;Unknown Alphanumeric

A clinical study should at a minimum use either the "time-based" or the "tissue-based" definition for clinical stroke. Some clinical studies may find it appropriate to use both definitions.

Sacco RL, Kasner SE, Broderick JP, Caplan LR, Connors JJ, Culebras A, Elkind MS, George MG, Hamdan AD, Higashida RT, Hoh BL, Janis LS, Kase CS, Kleindorfer DO, Lee JM, Moseley ME, Peterson ED, Turan TN, Valderrama AL, Vinters HV; American Heart Association Stroke Council, Council on Cardiovascular Surgery and Anesthesia; Council on Cardiovascular Radiology and Intervention; Council on Cardiovascular and Stroke Nursing; Council on Epidemiology and Prevention; Council on Peripheral Vascular Disease; Council on Nutrition, Physical Activity and Metabolism. An updated definition of stroke for the 21st century: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2013;44(7):2064-2089. Available at: http://stroke.ahajournals.org. Adult;Pediatric Supplemental?Highly Recommended 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C14259 Pediatric Stroke Classification (PSC) - sub type PSCSubTyp Pediatric Stroke Classification (PSC) system (Wraige, 2005) subtype Pediatric Stroke Classification (PSC) system (Wraige, 2005) subtype Indicate the Pediatric Stroke Classification (PSC) system subtype Sickle cell disease;Cardioembolic;Moyamoya Syndrome;Cervical arterial dissection;Steno-occlusive cerebral arteriopathy;Other determined etiology;Multiple probable/ possible etiologies;Undetermined etiology Sickle cell disease;Cardioembolic;Moyamoya Syndrome;Cervical arterial dissection;Steno-occlusive cerebral arteriopathy;Other determined etiology;Multiple probable/ possible etiologies;Undetermined etiology Alphanumeric

No instructions available

Wraige E, Pohl KR, Ganesan V. A proposed classification for subtypes of arterial ischemic stroke in children. Dev Med Child Neurol. 2005;47(4):252-256. Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C14233 Atherosclerosis small vessel disease cardiac source other cause (ASCO) system - other grade ASCOSystemOtherGrade The grade of other cause, as part of the atherosclerosis small-vessel disease cardiac source other cause (ASCO) system. Patients are evaluated for the predefined phenotype of other cause (O) The grade of other cause, as part of the atherosclerosis small-vessel disease cardiac source other cause (ASCO) system. Patients are evaluated for the predefined phenotype of other cause (O) Evaluate the patients for the predefined phenotype of other cause (O). 0;1;2;3;9 No disease is present;Definitely a potential cause of the index stroke (examples): (a) Arterial dissection by A or B evidence (table 3), (b) Dolichoectasia with complicated aneurysm, (c) Polycythemia vera, thrombocythemia >800,000/mm3, (d) Lupus erythematosus, (e) Disseminated intravascular coagulation, (f) Criteria for antiphospholipid antibody syndrome, (g) Fabry's disease, (h) Concomitant meningitis, (i) Sickle cell disease, (j) Ruptured cerebral aneurysm with or without demonstration of spasm in the territory of the brain infarct, (k) Homozygote for hyperhomocystinuria;Causality uncertain: (a) Arterial dissection diagnosed by level C evidence, (b) Fibromuscular dysplasia;Unlikely a direct cause of index stroke (but disease is present): (a) Kinking or dolichoectasia without complicated aneurysm or plicature, (b) Arteriovenous malformation or saccular aneurysm, (c) Thrombocytosis >450,000 and <800,000/mm3, (d) Antiphospholipid antibodies <100 GPL units, (e) Mild hyperhomocysteinemia heterozygote;Cannot be graded because no tests were performed Numeric values

This data element should be collected along with the other elements from the A-S-C-O (Phenotypic) Classification.

Amarenco P, Bogousslavsky J, Caplan LR, Donnan GA, Hennerici MG. New approach to stroke subtyping: the A-S-C-O (phenotypic) classification of stroke. Cerebrovasc Dis. 2009;27(5):502-508 Adult Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C14626 Sophia delivery mode type SophiaDelModeTyp Mother's mode of delivery of the neonate. This variable is included along with 8 other classifying variables and clinical context in the Sophia Composite Diagnostic Classification. Mother's mode of delivery of the neonate. This variable is included along with 8 other classifying variables and clinical context in the Sophia Composite Diagnostic Classification. Identify the mother's mode of delivery of the neonate. Spontaneous cephalic vaginal;Cephalic vaginal with instrumental traction (vacuum, forceps or both);Breech vaginal;Elective caesarean;Emergency caesarean Spontaneous cephalic vaginal;Cephalic vaginal with instrumental traction (vacuum, forceps or both);Breech vaginal;Elective caesarean;Emergency caesarean Alphanumeric

This element should be collected along with the other elements of the Sophia Classification.

Govaert P, Ramenghi L, Taal R, de Vries L, Deveber G. Diagnosis of perinatal stroke I: definitions, differential diagnosis and registration. Acta Paediatr. 2009;98(10):1556-1567. Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C14249 Subarachnoid hemorrhage interhemispheric fissure score SubarachHemInterhemFisScore Subarachnoid hemorrhage column scale (Hijdra) for the interhemispheric fissure score SAH Volume Scale (Hijdra) - Interhemispheric fissure score Column scale (Hijdra) for the interhemispheric fissure score 0;1;2;3 No blood;Small amount of blood;Moderately filled with blood;Completely filled with blood Numeric values

This data element should be collected along with the other elements of the SAH Volume Scale (Hijdra).

Hijdra A, Brouwers PJ, Vermeulen M, van Gijn J. Grading the amount of blood on computed tomograms after subarachnoid hemorrhage. Stroke 1990;21(8):1156-1161. Adult;Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C14220 Clinical stroke tissue-based definition indicator ClinStrokeTissBasedDefinInd Indicates whether the patient suffered a clinical stroke according to the following, "tissue-based" definition: Symptomatic stroke is a sudden focal neurological deficit, of any duration, due to focal brain, spinal cord, or retinal infarction or hemorrhage. Infarction or hemorrhage may be demonstrated either 1) directly by imaging/laboratory/pathologic examination in patients with symptom duration less than 24 hours, or 2) inferred by symptoms lasting >= 24 hours (or fatal within 24 hours) that cannot be attributed to another cause. Indicates whether the patient suffered a clinical stroke according to a "tissue-based" definition. Has the patient suffered a clinical stroke according to the "tissue-based" definition? Yes;No;Unknown Yes;No;Unknown Alphanumeric

A clinical study should at a minimum use either the "time-based" or the "tissue-based" definition for clinical stroke. Some clinical studies may find it appropriate to use both definitions.

Sacco RL, Kasner SE, Broderick JP, Caplan LR, Connors JJ, Culebras A, Elkind MS, George MG, Hamdan AD, Higashida RT, Hoh BL, Janis LS, Kase CS, Kleindorfer DO, Lee JM, Moseley ME, Peterson ED, Turan TN, Valderrama AL, Vinters HV; American Heart Association Stroke Council, Council on Cardiovascular Surgery and Anesthesia; Council on Cardiovascular Radiology and Intervention; Council on Cardiovascular and Stroke Nursing; Council on Epidemiology and Prevention; Council on Peripheral Vascular Disease; Council on Nutrition, Physical Activity and Metabolism. An updated definition of stroke for the 21st century: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2013;44(7):2064-2089. <br />Available at: http://stroke.ahajournals.org. Adult;Pediatric Supplemental?Highly Recommended 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C14260 Sebire-International Pediatric Stroke Study (IPSS) - sub type SebireIPSSSubTyp The subtype as related to the Sebire/International Pediatric Stroke Study (IPSS) classification. The subtype as related to the Sebire/International Pediatric Stroke Study (IPSS) classification. Indicate the subtype as related to the Sebire/International Pediatric Stroke Study (IPSS) classification. Arteriopathy associated with sickle cell disease;Transient cerebral arteriopathy;Moyamoya Syndrome;Arterial dissection;Chronic inflammatory vasculitis;Neurofibromatosis type 1 (NF1);Fibromuscular dysplasia;Post irradiation arteriopathy;Metabolic arteriopathies;Cryptogenic arteriopathy Arteriopathy associated with sickle cell disease;Transient cerebral arteriopathy;Moyamoya Syndrome;Arterial dissection;Chronic inflammatory vasculitis;Neurofibromatosis type 1 (NF1);Fibromuscular dysplasia;Post irradiation arteriopathy;Metabolic arteriopathies;Cryptogenic arteriopathy Alphanumeric

No instructions available

Sebire G, Fullerton H, Riou E, deVeber G. Toward the definition of cerebral arteriopathies of childhood. Curr Opin Pediatr. 2004;16(6):617-622. Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C14234 Atherosclerosis small vessel disease cardiac source other cause (ASCO) system - diagnostic evidence level type ASCOSystemDiagEvidLevTyp Levels of diagnostic evidence for the ASCO Grades Levels of diagnostic evidence for the ASCO Grades Identify the levels of diagnostic evidence for the ASCO grades. Level A;Level B;Level C Direct demonstration by gold standard diagnostic tests or criteria;Indirect evidence or less sensitive or specific tests or criteria;Weak evidence Alphanumeric

This data element should be collected along with the other elements from the A-S-C-O (Phenotypic) Classification.

Amarenco P, Bogousslavsky J, Caplan LR, Donnan GA, Hennerici MG. New approach to stroke subtyping: the A-S-C-O (phenotypic) classification of stroke. Cerebrovasc Dis. 2009;27(5):502-508 Adult Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C18909 Intracerebral hemorrhage presumed cause other text ICHPresumedCauseOTH The free-text field related to 'Intracerebral hemorrhage presumed cause type' specifying other text. Indicates the presumed cause(s) of the intracerebral hemorrhage (ICH). Multiple responses are allowed. The free-text field related to 'Intracerebral hemorrhage presumed cause type' specifying other text. Indicates the presumed cause(s) of the intracerebral hemorrhage (ICH). Multiple responses are allowed. Other, specify Alphanumeric

No instructions available

No references available Adult;Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events 4000

Free-Form Entry

C00001 Gestational age value GestatnlAgeVal Time elapsed in weeks between the first day of the last normal menstrual period and the day of delivery of the participant/subject. Time elapsed in weeks between the first day of the last normal menstrual period and the day of delivery of the participant/subject. Gestational age at birth Numeric Values

Enter the gestational age at birth in weeks as an integer.

No references available Pediatric Supplemental 3.00 2013-07-25 08:54:08.2 Stroke Types and Subtypes Classification Disease/Injury Related Events

Free-Form Entry

0 52 week 3192017
C14250 Subarachnoid hemorrhage Sylvian fissure lateral part score SubaracHemSylvianFisLatPaScore SAH Volume Scale (Hijdra) - Sylvian fissure lateral part left score SAH Volume Scale (Hijdra) - Sylvian fissure lateral part left score Sylvian fissure lateral part left score 0;1;2;3 No blood;Small amount of blood;Moderately filled with blood;Completely filled with blood Numeric values

This data element should be collected along with the other elements of the SAH Volume Scale (Hijdra).

Hijdra A, Brouwers PJ, Vermeulen M, van Gijn J. Grading the amount of blood on computed tomograms after subarachnoid hemorrhage. Stroke. 1990;21(8):1156-1161. Adult;Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C14221 Clinical stroke time-based definition type ClinStrokeTimeBasedDefinTyp Indicates the type of clinical stroke suffered by the adult patient, using duration of symptoms to distinguish between ischemic stroke and TIA. Indicates the type of clinical stroke suffered by the adult patient, using duration of symptoms to distinguish between ischemic stroke and TIA. Indicate the type of clinical stroke suffered by the adult patient, using the duration of symptoms to distinguish between ischemic stroke and TIA. Ischemic Stroke;Transient Ischemic Attack (TIA);Intracerebral hemorrhage (ICH);Intraventricular hemorrhage (IVH);Subarachnoid hemorrhage (SAH);Clinical Stroke of Uncertain Type;Silent Stroke (Clinically Asymptomatic) Ischemic Stroke;Transient Ischemic Attack (TIA);Intracerebral hemorrhage (ICH);Intraventricular hemorrhage (IVH);Subarachnoid hemorrhage (SAH);Clinical Stroke of Uncertain Type;Silent Stroke (Clinically Asymptomatic) Alphanumeric

Choose one per stroke event. A clinical study should use either the "time-based" or "tissue-based" definition for clinical stroke type.

The "NINDS Stroke Common Data Element (CDE) Project, Stroke Types and Subtypes Subgroup: Recommendations" has detailed definitions for each stroke type. That document also suggests using a term like "Acute Neurovascular Syndrome" for patients with relatively brief symptom duration (e.g., symptoms that persist several hours but less than a day), who do not receive a detailed diagnostic imaging evaluation and thus it is not possible to determine whether stroke or TIA is the most appropriate diagnosis. <br />Sacco RL, Kasner SE, Broderick JP, Caplan LR, Connors JJ, Culebras A, Elkind MS, George MG, Hamdan AD, Higashida RT, Hoh BL, Janis LS, Kase CS, Kleindorfer DO, Lee JM, Moseley ME, Peterson ED, Turan TN, Valderrama AL, Vinters HV; American Heart Association Stroke Council, Council on Cardiovascular Surgery and Anesthesia; Council on Cardiovascular Radiology and Intervention; Council on Cardiovascular and Stroke Nursing; Council on Epidemiology and Prevention; Council on Peripheral Vascular Disease; Council on Nutrition, Physical Activity and Metabolism. An updated definition of stroke for the 21st century: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2013;44(7):2064-2089.<br />Available at: http://stroke.ahajournals.org. Adult;Pediatric Supplemental?Highly Recommended 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C14261 Childhood AIS standardized classification and diagnostic evaluation (CASCADE) - standard primary acute sub type CASCADEStandPrimryAcuteSubTyp Childhood AIS Standardized Classification and Diagnostic Evaluation (CASCADE) Primary Classification: Acute - All patients with defined childhood arterial ischemic stroke will be classified into a single acute primary category, at the time of initial diagnosis (within 1 month of presentation). Childhood AIS standardized classification and diagnostic evaluation (CASCADE) primary classification: acute subtype Primary Classification: Acute – All patients with defined childhood arterial ischemic stroke will be classified into a single acute primary category, at the time of initial diagnosis (within 1 month of presentation). Small vessel arteriopathy of childhood (SVA);Unilateral focal cerebral arteriopathy of childhood (FCA);Bilateral cerebral arteriopathy of childhood;Aortic/ cervical arteriopathy;Cardio- embolic;Other;Multi-factorial;Undetermined etiology Small vessel arteriopathy of childhood (SVA);Unilateral focal cerebral arteriopathy of childhood (FCA);Bilateral cerebral arteriopathy of childhood;Aortic/ cervical arteriopathy;Cardio- embolic;Other;Multi-factorial;Undetermined etiology Alphanumeric

This data element should be collected along with the other elements of the CASCADE criteria.

Bernard TJ, Beslow LA, Manco-Johnson MJ, Armstrong-Wells J, Boada R, Weitzenkamp D, Hollatz A, Poisson S, Amlie-Lefond C, Lo W, deVeber G, Goldenberg NA, Dowling MM, Roach ES, Fullerton HJ, Benseler SM, Jordan LC, Kirton A, Ichord RN. Inter-Rater Reliability of the CASCADE Criteria: Challenges in Classifying Arteriopathies. Stroke. 2016;47(10):2443-2449.<br /><br />Bernard TJ, Manco-Johnson MJ, Lo W, MacKay MT, Ganesan V, DeVeber G, Goldenberg NA, Armstrong-Wells J, Dowling MM, Roach ES, Tripputi M, Fullerton HJ, Furie KL, Benseler SM, Jordan LC, Kirton A, Ichord R. Towards a consensus-based classification of childhood arterial ischemic stroke. Stroke. 2012;43(2):371-377. Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events

Single Pre-Defined Value Selected

C14235 Atherosclerosis small vessel disease cardiac source other cause (ASCO) system - sub type ASCOSystemSubTyp Stroke Subtype as defined by the A-S-C-O pattern (e.g., A1-S3-C1-O3) Stroke Subtype as defined by the A-S-C-O pattern (e.g., A1-S3-C1-O3) Identify the Stroke Subtype as defined by the A-S-C-O pattern Alphanumeric

This element combines the 4 separate phenotype grades. It should be collected along with the other elements from the A-S-C-O (Phenotypic) Classification. The format is A_S_C_O_ ; where blanks contain numbers 0, 1, 2, 3 or 9.

Amarenco P, Bogousslavsky J, Caplan LR, Donnan GA, Hennerici MG. New approach to stroke subtyping: the A-S-C-O (phenotypic) classification of stroke. Cerebrovasc Dis. 2009;27(5):502-508 Adult Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events 255

Free-Form Entry

C18910 Intraventricular hemorrhage presumed cause other text IVHPresumedCauseOTH The free-text field related to 'Intraventricular hemorrhage presumed cause type' specifying other text. Indicates the presumed cause(s) of the intraventricular hemorrhage (IVH). Multiple responses are allowed. The free-text field related to 'Intraventricular hemorrhage presumed cause type' specifying other text. Indicates the presumed cause(s) of the intraventricular hemorrhage (IVH). Multiple responses are allowed. Other, specify Alphanumeric

No instructions available

No references available Adult;Pediatric Supplemental 3.00 2013-06-21 00:00:00.0 Stroke Types and Subtypes Classification Disease/Injury Related Events 4000

Free-Form Entry

CSV