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Migraine Functional Impact Questionnaire (MFIQ)
Availability
Please contact desaip@amgen.com for more information on how to access the Migraine Functional Impact Questionnaire.
Classification
Exploratory: Headache
Short Description of Instrument
The Migraine Functional Impact Questionnaire (MFIQ) is a 26-item self-administered instrument which assesses the impact of migraine on physical functioning, usual activities, social functioning, and emotional functioning over the past seven days.
 
It was developed with patient input and refined through an iterative process using both qualitative and quantitative methods, following best practices for PRO instrument development, to reflect patients’ perspective about the impact of migraine on their functioning. Development and validation of the MFIQ also included guidance from phycometricians and experts in the field of migraine management.
Scoring
Subjects respond to items using a 5-point scale assigned scores from 1 to 5, with 5 representing the greatest burden. MFIQ has four domain scores, Impact on Physical Function (PF; 5 items), Impact on Usual Activities (UA; 10 items), Impact on Social Function (SF; 5 items), and Impact on Emotional Function (EF; 5 items), and a global assessment of Overall Impact on Usual Activities (G-UA; single item). The scores are calculated as the sum of the item responses and the sum is rescaled to a 0 – 100 scale, with higher scores representing greater burden.
Psychometric Properties
MFIQ domain scores (0–100: higher score=greater impact) demonstrated good internal consistency (α>0.90) and test-retest reliability (ICC>0.50).
 
Moderate to large correlations (all p<0.0001) demonstrated convergent validity between MFIQ domain scores and related constructs, including number of migraine days (r=0.39 to 0.46), HIT-6™ score (r=0.55 to 0.73), and MSQ domain scores (r=-0.60 to -0.81).
MFIQ domain scores at week 4 differentiated between groups varying with respect to migraine days (p<0.001) and headache impact level based on HIT-6™, supporting known-groups validity.
A pattern was observed of higher MFIQ domain scores corresponding to groups with greater numbers of migraine days during the 4 weeks, indicating that higher impact was related to having more days with migraine.
References
Mannix S, Skalicky A, Buse DC, Desai P, Sapra S, Ortmeier B, Widnell K, Hareendran A. Measuring the impact of migraine for evaluating outcomes of preventive treatments for migraine headaches. Health and Quality of Life Outcomes. 2016;14(1):143.
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